Cost-Effectiveness Analysis of Lung Cancer Screening in the United States
| العنوان: | Cost-Effectiveness Analysis of Lung Cancer Screening in the United States |
|---|---|
| المؤلفون: | Iakovos Toumazis, Erik F. Blom, Jihyoun Jeon, Kevin ten Haaf, Pianpian Cao, Deirdre F. Sheehan, Yufan Chen, Rafael Meza, Steven D. Criss, Sylvia K. Plevritis, Mehrad Bastani, Harry J. de Koning, Chung Yin Kong |
| المساهمون: | Public Health, Health Technology Assessment (HTA) |
| المصدر: | Annals of Internal Medicine, 171:WOS:000506426000005, 796-804. American College of Physicians |
| بيانات النشر: | American College of Physicians, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Lung Neoplasms, Cost effectiveness, Cost-Benefit Analysis, 01 natural sciences, Sensitivity and Specificity, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Risk Factors, Internal Medicine, medicine, Humans, Mass Screening, 030212 general & internal medicine, 0101 mathematics, Overdiagnosis, Lung cancer, Early Detection of Cancer, health care economics and organizations, Aged, Aged, 80 and over, Models, Statistical, business.industry, 010102 general mathematics, Smoking, General Medicine, Cost-effectiveness analysis, Middle Aged, medicine.disease, United States, Quality-adjusted life year, Clinical trial, Quality of Life, National Lung Screening Trial, business, Tomography, X-Ray Computed, Lung cancer screening, Demography |
| الوصف: | Background Recommendations vary regarding the maximum age at which to stop lung cancer screening: 80 years according to the U.S. Preventive Services Task Force (USPSTF), 77 years according to the Centers for Medicare & Medicaid Services (CMS), and 74 years according to the National Lung Screening Trial (NLST). Objective To compare the cost-effectiveness of different stopping ages for lung cancer screening. Design By using shared inputs for smoking behavior, costs, and quality of life, 4 independently developed microsimulation models evaluated the health and cost outcomes of annual lung cancer screening with low-dose computed tomography (LDCT). Data sources The NLST; Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial; SEER (Surveillance, Epidemiology, and End Results) program; Nurses' Health Study and Health Professionals Follow-up Study; and U.S. Smoking History Generator. Target population Current, former, and never-smokers aged 45 years from the 1960 U.S. birth cohort. Time horizon 45 years. Perspective Health care sector. Intervention Annual LDCT according to NLST, CMS, and USPSTF criteria. Outcome measures Incremental cost-effectiveness ratios (ICERs) with a willingness-to-pay threshold of $100 000 per quality-adjusted life-year (QALY). Results of base-case analysis The 4 models showed that the NLST, CMS, and USPSTF screening strategies were cost-effective, with ICERs averaging $49 200, $68 600, and $96 700 per QALY, respectively. Increasing the age at which to stop screening resulted in a greater reduction in mortality but also led to higher costs and overdiagnosis rates. Results of sensitivity analysis Probabilistic sensitivity analysis showed that the NLST and CMS strategies had higher probabilities of being cost-effective (98% and 77%, respectively) than the USPSTF strategy (52%). Limitation Scenarios assumed 100% screening adherence, and models extrapolated beyond clinical trial data. Conclusion All 3 sets of lung cancer screening criteria represent cost-effective programs. Despite underlying uncertainty, the NLST and CMS screening strategies have high probabilities of being cost-effective. Primary funding source CISNET (Cancer Intervention and Surveillance Modeling Network) Lung Group, National Cancer Institute. |
| تدمد: | 1539-3704 0003-4819 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f0d7a521b54a994849e86476fd9a93 https://doi.org/10.7326/M19-0322 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....87f0d7a521b54a994849e86476fd9a93 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15393704 00034819 |
|---|