Dietary Protein Source Influences Brain Inflammation and Memory in a Male Senescence-Accelerated Mouse Model of Dementia
| العنوان: | Dietary Protein Source Influences Brain Inflammation and Memory in a Male Senescence-Accelerated Mouse Model of Dementia |
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| المؤلفون: | Marco Virgili, Barbara Monti, Emiliano Peña-Altamira, Valentina Ravaioli, Cristina Parenti, Sabrina Petralla, Irene Fancello, Francesca Massenzio |
| المساهمون: | Sabrina Petralla, Cristina Parenti, Valentina Ravaioli, Irene Fancello, Francesca Massenzio, Marco Virgili, Barbara Monti, Emiliano Pena-Altamira |
| المصدر: | Molecular Neurobiology. 58:1312-1329 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Senescence, Aging, medicine.medical_specialty, Neurogenesis, Neuroscience (miscellaneous), Inflammation, Brain damage, Systemic inflammation, 03 medical and health sciences, Cellular and Molecular Neuroscience, Cognition, 0302 clinical medicine, Memory, Internal medicine, Nerve Growth Factor, Autophagy, medicine, Animals, Dementia, Gliosis, Neuroinflammation, business.industry, Body Weight, Gliosi, Feeding Behavior, medicine.disease, Diet, Disease Models, Animal, Oligodendroglia, Ageing, 030104 developmental biology, Endocrinology, Neurology, Astrocytes, Encephalitis, Dietary Proteins, Microglia, medicine.symptom, business, Biomarkers, 030217 neurology & neurosurgery |
| الوصف: | Dementia is a pathological condition characterized by a decline in memory, as well as in other cognitive and social functions. The cellular and molecular mechanisms of brain damage in dementia are not completely understood; however, neuroinflammation is involved. Evidence suggests that chronic inflammation may impair cognitive performance and that dietary protein source may differentially influence this process. Dietary protein source has previously been shown to modify systemic inflammation in mouse models. Thus, we aimed to investigate the effect of chronic dietary protein source substitution in an ageing and dementia male mouse model, the senescence-accelerated mouse-prone 8 (SAMP8) model. We observed that dietary protein source differentially modified memory as shown by inhibitory avoidance testing at 4 months of age. Also, dietary protein source differentially modified neuroinflammation and gliosis in male SAMP8 mice. Our results suggest that chronic dietary protein source substitution may influence brain ageing and memory-related mechanisms in male SAMP8 mice. Moreover, the choice of dietary protein source in mouse diets for experimental purposes may need to be carefully considered when interpreting results. |
| وصف الملف: | ELETTRONICO |
| تدمد: | 1559-1182 0893-7648 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8821f02ece3b565ab827911c62773757 https://doi.org/10.1007/s12035-020-02191-y |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....8821f02ece3b565ab827911c62773757 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15591182 08937648 |
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