Identification of differentially expressed genes in the developing antler of red deer Cervus elaphus
| العنوان: | Identification of differentially expressed genes in the developing antler of red deer Cervus elaphus |
|---|---|
| المؤلفون: | Adrienn Borsy, István Gyurján, Andrea Agnes Molnar, Eva Korpos, Péter Papp, Zsuzsanna Buzás, Zoltán Zomborszky, Ferenc Deák, Ibolya Kiss, Viktor Stéger, László Orosz |
| المصدر: | Molecular Genetics and Genomics. 277:237-248 |
| بيانات النشر: | Springer Science and Business Media LLC, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Male, Apolipoprotein D, DNA, Complementary, Annexins, Mesenchyme, Cellular differentiation, Antlers, Biology, Mice, Species Specificity, Sequence Homology, Nucleic Acid, Gene expression, Genetics, medicine, Animals, Humans, RNA, Messenger, Cloning, Molecular, Molecular Biology, Gene, In Situ Hybridization, Base Sequence, Deer, Gene Expression Profiling, Gene Expression Regulation, Developmental, General Medicine, Immunohistochemistry, Antler, Cell biology, medicine.anatomical_structure, Velvet antler, Immunology, Chondrogenesis, Developmental biology |
| الوصف: | Understanding the molecular mechanisms underlying bone development is a fundamental and fascinating problem in developmental biology, with significant medical implications. Here, we have identified the expression patterns for 36 genes that were characteristic or dominant in the consecutive cell differentiation zones (mesenchyme, precartilage, cartilage) of the tip section of the developing velvet antler of red deer Cervus elaphus. Two major functional groups of these genes clearly outlined: six genes linked to high metabolic demand and other five to tumor biology. Our study demonstrates the advantages of the antler as a source of mesenchymal markers, for distinguishing precartilage and cartilage by different gene expression patterns and for identifying genes involved in the robust bone development, a striking feature of the growing antler. Putative roles for "antler" genes that encode alpha-tropomyosine (tpm1), transgelin (tagln), annexin 2 (anxa2), phosphatidylethanolamine-binding protein (pebp) and apolipoprotein D (apoD) in intense but still controlled tissue proliferation are discussed. |
| تدمد: | 1617-4623 1617-4615 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885fe09329a2135ceeeb690c8a8dc455 https://doi.org/10.1007/s00438-006-0193-x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....885fe09329a2135ceeeb690c8a8dc455 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 16174623 16174615 |
|---|