Metastatic Small Cell Malignant Melanoma: A Case Requiring Immunoelectronmicroscopy for the Demonstration of Lattice-deficient Melanosomes
| العنوان: | Metastatic Small Cell Malignant Melanoma: A Case Requiring Immunoelectronmicroscopy for the Demonstration of Lattice-deficient Melanosomes |
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| المؤلفون: | Saumitra S Banerjee, Jill Moss, Brian P Eyden, Ian Shore |
| المصدر: | Ultrastructural Pathology. 29:71-78 |
| بيانات النشر: | Informa UK Limited, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Male, Pathology, medicine.medical_specialty, Skin Neoplasms, Biology, Cell morphology, Small-cell carcinoma, Pathology and Forensic Medicine, Diagnosis, Differential, Neoplasms, Multiple Primary, Cytokeratin, Immunolabeling, Microscopy, Electron, Transmission, Structural Biology, medicine, Humans, Microscopy, Immunoelectron, Melanoma, Aged, Melanosomes, S100 Proteins, Histology, medicine.disease, Immunohistochemistry, Carcinoma, Basal Cell, Small-cell melanoma, Lymphatic Metastasis, Ultrastructure, Keratins, Neoplasm Recurrence, Local |
| الوصف: | A case of metastatic malignant melanoma exhibiting small cell morphology is described. The patient had had a previous primary nodular small cell melanoma. The metastatic tumor was examined by conventional histology, light microscope immunohistochemistry, conventional electron microscopy, and ultrastructural immunolabeling. It consisted of small cells, which, however, varied in size and were present in distinct but merging areas. Tumor cells were negative for S-100 protein and very focally positive for cytokeratin: these findings in combination with small cell morphology suggested the possibility of small cell carcinoma. However, other melanocytic markers were positive. Neuroendocrine markers were negative. By electron microscopy, tumor cells lacked unambiguous melanosomes but contained paranuclear aggregates of nondescript granules. Following ultrastructural immunolabeling, these were found to be decorated with gold-labeled HMB-45 antibodies, thereby confirming them as lattice-deficient melanosomes. This tumor is an uncommon example of malignant melanoma where immunoultrastructural analysis helped clarify the nature of otherwise nondescript granules as true but lattice-deficient melanosomes. This is also the first case of small cell melanoma to be studied by electron microscopy. |
| تدمد: | 1521-0758 0191-3123 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8866babb14a562384dda6f9fc1a427f4 https://doi.org/10.1080/01913120590910612 |
| رقم الأكسشن: | edsair.doi.dedup.....8866babb14a562384dda6f9fc1a427f4 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15210758 01913123 |
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