CT‐IGFBP‐4 as a novel prognostic biomarker in acute heart failure
| العنوان: | CT‐IGFBP‐4 as a novel prognostic biomarker in acute heart failure |
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| المؤلفون: | Alexander B. Postnikov, Alexey A. Konev, Fedor N. Rozov, Alexey G. Katrukha, Alexey V. Kharitonov, Daria V. Serebryanaya, Johan Lassus, Evgeny P. Altshuler, Veli-Pekka Harjola |
| المساهمون: | HUS Heart and Lung Center, Department of Medicine, Kardiologian yksikkö, University of Helsinki, HUS Emergency Medicine and Services, Department of Diagnostics and Therapeutics |
| المصدر: | ESC Heart Failure, Vol 7, Iss 2, Pp 434-444 (2020) ESC Heart Failure |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | N-terminal pro brain natriuretic peptide (NT-proBNP), 030204 cardiovascular system & hematology, Coronary artery disease, 0302 clinical medicine, MARKERS, Original Research Articles, Original Research Article, 030212 general & internal medicine, Myocardial infarction, PREDICTORS, RISK, OUTCOMES, Hazard ratio, Area under the curve, Prognosis, 3. Good health, Insulin-like growth factor binding protein 4 (IGFBP-4) fragments, Cardiology, Cardiology and Cardiovascular Medicine, Prognostic value, hormones, hormone substitutes, and hormone antagonists, medicine.medical_specialty, Acute coronary syndrome, Pregnancy‐associated plasma protein‐A (PAPP‐A), Heart failure, DIAGNOSIS, Risk Assessment, EVENTS, 03 medical and health sciences, PLASMA-PROTEIN, Internal medicine, medicine, Humans, Diseases of the circulatory (Cardiovascular) system, Models, Statistical, Receiver operating characteristic, business.industry, MORTALITY, Insulin‐like growth factor binding protein 4 (IGFBP‐4) fragments, Biomarker, medicine.disease, Peptide Fragments, N‐terminal pro brain natriuretic peptide (NT‐proBNP), Blood pressure, Insulin-Like Growth Factor Binding Protein 4, 3121 General medicine, internal medicine and other clinical medicine, RC666-701, IGFBP-4 FRAGMENTS, PAPP-A, 3111 Biomedicine, Pregnancy-associated plasma protein-A (PAPP-A), Tomography, X-Ray Computed, business, Biomarkers |
| الوصف: | Aims Insulin-like growth factor binding protein-4 (IGFBP-4) fragments have been shown to predict the risk of major adverse cardiovascular events, including segment-elevation myocardial infarction, in patients with acute coronary syndrome. We evaluated the prognostic value of the carboxy-terminal fragment of IGFBP-4 (CT-IGFBP-4) for all-cause mortality in emergency room patients with acute heart failure (AHF). Methods and results CT-IGFBP-4, N-terminal pro brain natriuretic peptide (NT-proBNP), and C-reactive protein (CRP) were measured at admission from the lithium-heparin plasma of 156 patients with AHF. All-cause mortality was recorded for 1 year. Receiver operator characteristic (ROC) curves, Kaplan-Meier, and Cox proportional hazard ratio analyses were performed to evaluate the prognostic value of the various clinical variables, CT-IGFBP-4, NT-proBNP, CRP, and their combinations. During 1 year of follow-up, 52 (33.3%) patients died. CT-IGFBP-4 only weakly correlated with NT-proBNP (Pearson correlation coefficient r = 0.16, P = 0.044) and did not correlate with CRP (r = 0.08, P = 0.35), emphasizing the different nature of these biomarkers. The receiver operator characteristic area under the curve (ROC AUC) of CT-IGFBP-4 for the prediction of all-cause mortality (0.727) was significantly higher than that of NT-proBNP (0.680, P = 0.045) and CRP (0.669, P = 0.016). The combination of CT-IGFBP-4, NT-proBNP, and CRP predicted mortality significantly better (ROC AUC = 0.788) than any of the biomarkers alone (P |
| تدمد: | 2055-5822 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888e6b900add0095b685d6a567778910 https://doi.org/10.1002/ehf2.12590 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....888e6b900add0095b685d6a567778910 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20555822 |
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