Skin prick reactivity among asthmatics in East Africa
| العنوان: | Skin prick reactivity among asthmatics in East Africa |
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| المؤلفون: | George Nyale, David W. Denning, Robin Gore, Hellen Aanyu-Tukamuhebwa, Levicatus Mugenyi, Corina de Jong, Bruce Kirenga, Vincent Wadda, Jeremiah Chakaya, Richard Kwizera, Getnet Yimer, Thys van der Molen |
| المساهمون: | Groningen Research Institute for Asthma and COPD (GRIAC) |
| المصدر: | The World Allergy Organization journal, 13(6):100130. Elsevier World Allergy Organization Journal, Vol 13, Iss 6, Pp 100130-(2020) The World Allergy Organization Journal |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, lcsh:Immunologic diseases. Allergy, medicine.medical_specialty, Allergy, Immunology, COPD, Chronic obstructive pulmonary disease, SPT, Ig, Immunoglobulin, AQLQ, Asthma Quality of Life Questionnaire, medicine.disease_cause, Article, Atopy, 03 medical and health sciences, 0302 clinical medicine, Allergen, SPT, Skin prick testing, Interquartile range, immune system diseases, Internal medicine, medicine, Immunology and Allergy, 030223 otorhinolaryngology, Asthma, House dust mite, COPD, FEV, Forced Expiratory Volume, ASAP, African Severe Asthma Project, biology, business.industry, A. fumigatus, Aspergillus fumigatus, TB, Tuberculosis, Emergency department, IQR, Interquartile range, medicine.disease, biology.organism_classification, ACT, Asthma control test, East Africa, 3. Good health, respiratory tract diseases, 030228 respiratory system, HIV, Human immunodeficiency virus, Africa, business, lcsh:RC581-607 |
| الوصف: | Background: The burden of asthma in Africa is high, and yet the disease is not universally prioritised. Data on allergic asthma and its impact on asthma morbidity are limited in Africa. Our aim was to describe the distribution of skin prick positivity among asthmatics in Eastern Africa.Methods: From August 2016 to May 2018, 1671 asthmatic patients were enrolled from Uganda, Kenya, and Ethiopia as part of the African Severe Asthma Program clinical study. Skin prick testing was performed at baseline using a panel of 12 allergens, and factors associated with skin prick reactivity determined.Results: Of the 1, 671 patients recruited, 71% were female with a median age of 40 years, 93.6% were aged >15 years and the patterns of asthma symptom frequency was intermittent in 2.9%, mild persistent in 19.9%, moderate persistent in 42.6% and severe persistent in 34.6% at baseline. Self-reported triggers, were dust (92%), cold weather (89%), upper respiratory infections (84%), strong smells (79%) and exposure to tobacco (78%). The majority (90%) of the participants had at least 1 positive allergen reaction, with 0.9% participants reacting to all the 12 allergens. Participants commonly reacted to house dust mites (66%), Blomia tropicalis (62%), and the German cockroach (52%). Patients sensitized to more allergens (>2) had significantly reduced lung function (FEV ≤ 80%; p = 0.001) and were more likely to visit the emergency department due to asthma (p = 0.012). There was no significant relationship between number of allergens and measures of asthma control, quality of life, and other clinical outcomes. Only the country of origin was independently associated with atopy among African asthmatics.Conclusion: There is a high prevalence of skin prick positivity among East African patients with asthma, with the commonest allergen being house dust mite. Skin reactivity did not correlate well with asthma severity and poor asthma control. The relation between atopy, measured through skin prick testing, and measures of asthma control among asthma patients in Eastern Africa is unclear and needs further study.Trial registration: The ASAP study was registered prospectively. ClinicalTrials.gov Identifier: NCT03065920; Registration date: February 28, 2017; Last verified: February 28, 2017. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1939-4551 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::889044dea4e66a537dcb022dec57f75e https://research.rug.nl/en/publications/7eb98c99-b636-463e-8526-8f174b8bdc69 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....889044dea4e66a537dcb022dec57f75e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19394551 |
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