Non-Typhoidal Salmonella Bacteraemia - An Under-Recognized Feature of AIDS in African Adults
| العنوان: | Non-Typhoidal Salmonella Bacteraemia - An Under-Recognized Feature of AIDS in African Adults |
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| المؤلفون: | Anstead M. Kankwatira, Melita A. Gordon, Gershom Mwafulirwa |
| المصدر: | Tropical Doctor. 34:198-200 |
| بيانات النشر: | SAGE Publications, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Salmonella, 030231 tropical medicine, Non typhoidal salmonella, Bacteremia, HIV Infections, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Acquired immunodeficiency syndrome (AIDS), 030225 pediatrics, Internal medicine, medicine, Humans, Sida, AIDS-Related Opportunistic Infections, biology, business.industry, Public Health, Environmental and Occupational Health, biology.organism_classification, medicine.disease, Infectious Diseases, Africa, Salmonella Infections, Hospital admission, Tropical medicine, Immunology, Viral disease, business |
| الوصف: | Non-typhoidal salmonella (NTS) infections are severe, invasive and recurrent in the HIV-infected adult, and NTS are the commonest cause of hospital admission with bacteraemia in sub-Saharan Africa. NTS bacteraemia typically presents in patients with HIV/AIDS once the CD4 count falls below 200 cells/μL. In-patient mortality is 35%–60%, and is highest in patients with confusion or severe anaemia. Among survivors, 25%–45% may have single or multiple recurrences of NTS bacteraemia 1–6 months after the first illness, requiring retreatment. Diagnosis relies on blood culture, so in many areas this disease cannot be definitively diagnosed, and must be empirically treated. Treatment is guided by local antibiotic sensitivities; fluoroquinolones are particularly useful for initial treatment if there is multidrug reistance to other agents, and may result in lower recurrence rates than other agents. Where possible, long-term secondary chemoprophylaxis to prevent recurrence is advisable. Successful ARV treatment also prevents recurrence. There is inadequate knowledge about the epidemiology of carriage and transmission among at-risk populations. |
| تدمد: | 1758-1133 0049-4755 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88986ceaf79e77965f8ee5b2908bcec7 https://doi.org/10.1177/004947550403400404 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....88986ceaf79e77965f8ee5b2908bcec7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17581133 00494755 |
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