Synthesis of New Highly Functionalized 1H-Indole-2-carbonitriles via Cross-Coupling Reactions
| العنوان: | Synthesis of New Highly Functionalized 1H-Indole-2-carbonitriles via Cross-Coupling Reactions |
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| المؤلفون: | Yvan Carcenac, Moufida Romdhani-Younes, Asma Hrizi, Manon Cailler, Jérôme Thibonnet |
| المصدر: | Molecules Volume 26 Issue 17 Molecules, Vol 26, Iss 5287, p 5287 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Indole test, Chemistry, 1H-indole-2-carbonitriles, Pharmaceutical Science, Sonogashira coupling, Organic chemistry, Sonogashira, Stille, Combinatorial chemistry, Article, Coupling reaction, Analytical Chemistry, Stille reaction, QD241-441, Chemistry (miscellaneous), Suzuki–Miyaura, Drug Discovery, Molecular Medicine, Reactivity (chemistry), Heck, Physical and Theoretical Chemistry |
| الوصف: | An approach for the preparation of polysubstituted indole-2-carbonitriles through a cross-coupling reaction of compounds 1-(but-2-ynyl)-1H-indole-2-carbonitriles and 1-benzyl-3-iodo-1H-indole-2-carbonitriles is described. The reactivity of indole derivatives with iodine at position 3 was studied using cross-coupling reactions. The Sonogashira, Suzuki–Miyaura, Stille and Heck cross-couplings afforded a variety of di-, tri- and tetra-substituted indole-2-carbonitriles. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| DOI: | 10.3390/molecules26175287 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ed46972cf480322c795d635a78f1d7 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....88ed46972cf480322c795d635a78f1d7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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| DOI: | 10.3390/molecules26175287 |