The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-γ-induced cell death
| العنوان: | The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-γ-induced cell death |
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| المؤلفون: | Lixin Zheng, Alan Sher, Jennifer L. Cannons, Dragana Jankovic, Damien Chaussabel, Pamela L. Schwartzberg, Patricia Caspar, Wendy T. Watford, Michael J. Lenardo, Carl G. Feng, Sara Hieny, André Báfica |
| المصدر: | Nature Immunology. 9:1279-1287 |
| بيانات النشر: | Springer Science and Business Media LLC, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Programmed cell death, Innate immune system, Effector, Cell growth, Immunology, Biology, Article, Cell biology, Effector T-Lymphocyte, Immune system, medicine, Immunology and Allergy, Macrophage, Interferon gamma, medicine.drug |
| الوصف: | Mice deficient in the interferon-gamma (IFN-gamma)-inducible, immunity-related GTPase Irgm1 have defective host resistance to a variety of intracellular pathogens. This greater susceptibility to infection is associated with impaired IFN-gamma-dependent macrophage microbicidal activity in vitro. Here we show that Irgm1 also regulated the survival of mature effector CD4(+) T lymphocytes by protecting them from IFN-gamma-induced autophagic cell death. Mice deficient in both IFN-gamma and Irgm1 were 'rescued' from the lymphocyte depletion and greater mortality that occurs in mice singly deficient in Irgm1 after mycobacterial infection. Our studies identify a feedback mechanism in the T helper type 1 response that limits the detrimental effects of IFN-gamma on effector T lymphocyte survival while promoting the antimicrobial functions of IFN-gamma. |
| تدمد: | 1529-2916 1529-2908 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8940da564e4ad8eb0a8cadce5b24d6d9 https://doi.org/10.1038/ni.1653 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8940da564e4ad8eb0a8cadce5b24d6d9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15292916 15292908 |
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