CNTF and Nrf2 Are Coordinately Involved in Regulating Self-Renewal and Differentiation of Neural Stem Cell during Embryonic Development
| العنوان: | CNTF and Nrf2 Are Coordinately Involved in Regulating Self-Renewal and Differentiation of Neural Stem Cell during Embryonic Development |
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| المؤلفون: | Yu-xuan Hu, Beate Brand-Saberi, Guo-sheng Liu, Ya Jin, Guang Wang, Zhen-Peng Si, Xuesong Yang, Sha-sha Han, Mei-Yao He |
| المصدر: | iScience iScience, Vol 19, Iss, Pp 303-315 (2019) |
| بيانات النشر: | Elsevier, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Nervous system, 02 engineering and technology, Molecular neuroscience, Biology, Ciliary neurotrophic factor, Neuropoietic Cytokine, Article, 03 medical and health sciences, Developmental Neuroscience, medicine, lcsh:Science, Gliogenesis, Multidisciplinary, Embryogenesis, Neurogenesis, Diabetology, 021001 nanoscience & nanotechnology, Neural stem cell, 030104 developmental biology, medicine.anatomical_structure, biology.protein, lcsh:Q, Molecular Neuroscience, 0210 nano-technology, Neuroscience |
| الوصف: | Summary There is high risk of fetal neurodevelopmental defects in pregestational diabetes mellitus (PGDM). However, the effective mechanism of hyperglycemia-induced neurodevelopmental negative effects, including neural stem cell self-renewal and differentiation, still remains obscure. Neuropoietic cytokines have been shown to play a vital part during nervous system development and in the coordination of neurons and gliocytes. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) dysfunction might be related to a reduction of self-protective response in brain malformation induced by hyperglycemia. We therefore evaluated the role of Nrf2 and neuropoietic cytokines in fetal neurodevelopmental defects induced by PGDM and determined the mechanisms involved. Our data reveal that PGDM dramatically impairs the developmental switch of neural stem cells from neurogenesis to gliogenesis, principally under the cooperative mediation of neuropoietic cytokine CNTF and Nrf2 antioxidative signaling. This indicates that CNTF and Nrf2 could be potentially used in the prevention or therapy of neurodevelopmental defects of PGDM offspring. Graphical Abstract Highlights • Hyperglycemia affects self-renewal ability of neural progenitor cells • Hyperglycemia twists the developmental switch from neurogenesis into gliogenesis • CNTF regulates hyperglycemia-induced imbalance between neurogenesis and gliogenesis • CNTF and Nrf2 co-ordinately regulate neural development through p-STAT3 Molecular Neuroscience; Developmental Neuroscience; Diabetology |
| اللغة: | English |
| تدمد: | 2589-0042 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89442ab02d0122a3514871c0d21d5b57 http://europepmc.org/articles/PMC6700439 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....89442ab02d0122a3514871c0d21d5b57 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25890042 |
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