Receptor for Motilin Identified in the Human Gastrointestinal System
| العنوان: | Receptor for Motilin Identified in the Human Gastrointestinal System |
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| المؤلفون: | Sheng-Shung Pong, Mark Abramovitz, Andrew D. Howard, Rino Stocco, Ploeg, Raman K. Bakshi, Stacia Kargman, Carina P. Tan, Donna L. Hreniuk, Margaret A. Cascieri, David J. Figueroa, Ravi P. Nargund, Karen K. McKee, Jilly F. Evans, Scott D. Feighner, Lex H. T. Van Der, Christopher P. Austin, Oksana C. Palyha, Roy G. Smith, Douglas J. MacNeil, Arthur A. Patchett, Gary P. O'Neill |
| المصدر: | Science. 284:2184-2188 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Receptors, Neuropeptide, medicine.medical_specialty, Colon, G protein, Motilin receptor, Molecular Sequence Data, Thyroid Gland, Gastric motility, Peptide hormone, Biology, Ligands, Transfection, Cell Line, Receptors, Gastrointestinal Hormone, Motilin, GTP-Binding Proteins, Internal medicine, Heterotrimeric G protein, Intestine, Small, medicine, Humans, Amino Acid Sequence, Cloning, Molecular, Receptor, Antrum, In Situ Hybridization, Binding Sites, Multidisciplinary, Base Sequence, Chromosomes, Human, Pair 13, digestive, oral, and skin physiology, Chromosome Mapping, Erythromycin, Alternative Splicing, Endocrinology, Gastric Mucosa, Calcium, hormones, hormone substitutes, and hormone antagonists |
| الوصف: | Motilin is a 22–amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract of humans and other species. It affects gastric motility by stimulating interdigestive antrum and duodenal contractions. A heterotrimeric guanosine triphosphate–binding protein (G protein)–coupled receptor for motilin was isolated from human stomach, and its amino acid sequence was found to be 52 percent identical to the human receptor for growth hormone secretagogues. The macrolide antibiotic erythromycin also interacted with the cloned motilin receptor, providing a molecular basis for its effects on the human GI tract. The motilin receptor is expressed in enteric neurons of the human duodenum and colon. Development of motilin receptor agonists and antagonists may be useful in the treatment of multiple disorders of GI motility. |
| تدمد: | 1095-9203 0036-8075 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ab021e549d3705738c38c9def20ff8 https://doi.org/10.1126/science.284.5423.2184 |
| رقم الأكسشن: | edsair.doi.dedup.....89ab021e549d3705738c38c9def20ff8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
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