Oral Ingestion and Intraventricular Injection of Curcumin Attenuates the Effort-Related Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Motivational Symptoms of Depression
| العنوان: | Oral Ingestion and Intraventricular Injection of Curcumin Attenuates the Effort-Related Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Motivational Symptoms of Depression |
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| المؤلفون: | Robin H. Bogner, Samantha L Collins, Mercè Correa, Samantha E. Yohn, Dea Gorka, Emily Qian, John D. Salamone, Anisha Mistry, Arushi Manchanda |
| المساهمون: | Connecticut Diet and Health Initiative, University of Connecticut, Department of Psychological Sciences, University of Connecticut Research Foundation |
| المصدر: | Journal of Natural Products. 80:2839-2844 |
| بيانات النشر: | American Chemical Society (ACS), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, tetrabenazine, Curcumin, Tetrabenazine, Dietary supplement, Administration, Oral, Pharmaceutical Science, Pharmacology, Choice Behavior, Analytical Chemistry, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Curcuma, 0302 clinical medicine, Drug Discovery, Animals, Medicine, curcumin, Depression (differential diagnoses), Injections, Intraventricular, Motivation, Molecular Structure, Depression, business.industry, Organic Chemistry, Feeding Behavior, Rats, 030227 psychiatry, Monoamine neurotransmitter, Oral ingestion, Complementary and alternative medicine, chemistry, Vesicular Monoamine Transport Proteins, depression, Molecular Medicine, Lever pressing, business, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | Effort-related choice tasks are used for studying depressive motivational symptoms such as anergia/fatigue. These studies investigated the ability of the dietary supplement curcumin to reverse the low-effort bias induced by the monoamine storage blocker tetrabenazine. Tetrabenazine shifted effort-related choice in rats, decreasing high-effort lever pressing but increasing chow intake. The effects of tetrabenazine were reversed by oral ingestion of curcumin (80.0–160.0 mg/kg) and infusions of curcumin into the cerebral ventricles (2.0–8.0 μg). Curcumin attenuates the effort-related effects of tetrabenazine in this model via actions on the brain, suggesting that curcumin may be useful for treating human motivational symptoms. |
| تدمد: | 1520-6025 0163-3864 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0ba70c6648132ccf110e5714f76064 https://doi.org/10.1021/acs.jnatprod.7b00425 |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....8a0ba70c6648132ccf110e5714f76064 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15206025 01633864 |
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