Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas
| العنوان: | Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas |
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| المؤلفون: | Katja Beck, Ulrich Schüller, Matthias A. Karajannis, Daniel Schrimpf, Andrey Korshunov, Svenja Boekhoff, Christina Bluecher, Arie Perry, Hermann L. Müller, Priscilla K. Brastianos, Christian Mawrin, Jens Schittenhelm, Felix Sahm, Damian Stichel, Nagarajan Paramasivam, Natalie Waldt, Stefan M. Pfister, Matthias Schlesner, Torsten Pietsch, Philipp Sievers, David Capper, Markus J. Riemenschneider, Siegfried Kropf, Elmar Kirches |
| المصدر: | Acta neuropathologica, vol 142, iss 5 Acta Neuropathologica |
| بيانات النشر: | eScholarship, University of California, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, Pediatric Research Initiative, Adolescent, Clinical Sciences, Biology, DNA sequencing, Pathology and Forensic Medicine, Meningioma, Cellular and Molecular Neuroscience, Rare Diseases, Papillary Meningioma, Chromosome instability, medicine, otorhinolaryngologic diseases, Meningeal Neoplasms, Genetics, Humans, ddc:610, Child, Preschool, neoplasms, Cancer, Pediatric, Original Paper, Methylation profile, Neurology & Neurosurgery, Gene Expression Profiling, Human Genome, Neurosciences, medicine.disease, Dna methylation profiling, nervous system diseases, Brain Disorders, Brain Cancer, Child, Preschool, NF2, DNA methylation, Targeted sequencing, Female, Neurology (clinical), Unsupervised clustering, Transcriptome, Clear cell |
| الوصف: | In contrast to adults, meningiomas are uncommon tumors in childhood and adolescence. Whether adult and pediatric meningiomas differ on a molecular level is unclear. Here we report detailed genomic analyses of 37 pediatric meningiomas by sequencing and DNA methylation profiling. Histologically, the series was dominated by meningioma subtypes with aggressive behavior, with 70% of patients suffering from WHO grade II or III meningiomas. The most frequent cytogenetic aberrations were loss of chromosomes 22 (23/37 [62%]), 1 (9/37 [24%]), 18 (7/37 [19%]), and 14 (5/37 [14%]). Tumors with NF2 alterations exhibited overall increased chromosomal instability. Unsupervised clustering of DNA methylation profiles revealed separation into three groups: designated group 1 composed of clear cell and papillary meningiomas, whereas group 2A comprised predominantly atypical meningiomas and group 2B enriched for rare high-grade subtypes (rhabdoid, chordoid). Meningiomas from NF2 patients clustered exclusively within groups 1 and 2A. When compared with a dataset of 105 adult meningiomas, the pediatric meningiomas largely grouped separately. Targeted panel DNA sequencing of 34 tumors revealed frequent NF2 alterations, while other typical alterations found in adult non-NF2 tumors were absent. These data demonstrate that pediatric meningiomas are characterized by molecular features distinct from adult tumors. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a72798dded58bd3ab3dedeb1fa1ab15 https://escholarship.org/uc/item/9xd344rz |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8a72798dded58bd3ab3dedeb1fa1ab15 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |