Wound is caused by disruption of the integrity of body skin as a result of environ‐ mental or medical factors. Managing chronic and refractory wounds is a significant dilemma physicians are facing. Large varieties of treatment modalities have been used to enhance wound healing among which were different medicines, surgical proce‐ dures, physical therapy, hyperbaric oxygen therapy, and physical modalities such as laser and shockwave. In this chapter, the authors discuss physical modalities that are most used in the management of wound healing with a focus on lasers, shockwaves, photodynamic therapy, UVB therapy, and lights and describe some important experimental and clinical trials that have been done in this regard with an attempt to explain their mechanisms.