التفاصيل البيبلوغرافية
العنوان:
Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38alpha MAP kinase inhibitors with excellent in vivo antiinflammatory properties
المؤلفون:
Sehila Pleite , Mario Barberis , Robert Dean Dally , Eugenio de Diego , White Wesley Todd , Miriam del Prado , Concepcion Sanchez-Martinez , Timothy Alan Shepherd , Bryan D. Anderson , Luisa M. Martín Cabrejas , Chuan Shih , Jeffrey A. Wolos , Li C. Li , Carmen Dominguez , Alfonso De Dios , Beatriz López de Uralde , C. Richard Nevill , Enrique Jambrina , Arindam Chatterjee , Carlos Montero , Richard C. Schultz , Leticia Perez , Paul Lee , Carlos Jaramillo , Tiechao Li , María José Lorite , † Jaime Blanco-Urgoiti , John E. Toth , Robert M. Campbell , Rosanne Bonjouklian , Mary M. Mader
المصدر:
Bioorganicmedicinal chemistry letters . 18(1)
سنة النشر:
2007
مصطلحات موضوعية:
Imidazopyridine , Stereochemistry , Pyridines , Clinical Biochemistry , Anti-Inflammatory Agents , Pharmaceutical Science , Biochemistry , Chemical synthesis , Mitogen-Activated Protein Kinase 14 , Mice , Structure-Activity Relationship , Adenosine Triphosphate , In vivo , Drug Discovery , Structure–activity relationship , Potency , Animals , Edema , Humans , Molecular Biology , Mice, Inbred BALB C , biology , Chemistry , Tumor Necrosis Factor-alpha , Organic Chemistry , Imidazoles , In vitro , Peptide Fragments , Rats , ErbB Receptors , Enzyme inhibitor , Mitogen-activated protein kinase , biology.protein , Molecular Medicine , Benzimidazoles
الوصف:
Herein we report investigations into the p38alpha MAP kinase activity of trisubstituted imidazoles that led to the identification of compounds possessing highly potent in vivo activity. The SAR of a novel series of imidazopyridines is demonstrated as well, resulting in compounds possessing cellular potency and enhanced in vivo activity in the rat collagen-induced arthritis model of chronic inflammation.
تدمد:
1464-3405
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3ba94c85613579bee77218581f98d1 https://pubmed.ncbi.nlm.nih.gov/18039577
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....8b3ba94c85613579bee77218581f98d1
قاعدة البيانات:
OpenAIRE
