SOCS3 Attenuates GM-CSF/IFN-γ-Mediated Inflammation During Spontaneous Spinal Cord Regeneration
| العنوان: | SOCS3 Attenuates GM-CSF/IFN-γ-Mediated Inflammation During Spontaneous Spinal Cord Regeneration |
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| المؤلفون: | Tiancheng Song, Bingqiang He, Yi Luo, Hui Li, Yingjie Wang, Wenjuan Wang, Yongjun Wang, Yue Zhou, Xuejie Zhang, Xingxing Gu, Nan Du |
| المصدر: | Neuroscience Bulletin |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Spinal Cord Regeneration, Cord, Physiology, medicine.medical_treatment, Central nervous system, Inflammation, Proinflammatory cytokine, Interferon-gamma, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, SOCS3, Cytokine, Neurons, Spinal cord, Microglia, Vertebrate, business.industry, General Neuroscience, digestive, oral, and skin physiology, Granulocyte-Macrophage Colony-Stimulating Factor, Lizards, General Medicine, 030104 developmental biology, medicine.anatomical_structure, Suppressor of Cytokine Signaling 3 Protein, Cancer research, Original Article, medicine.symptom, business, 030217 neurology & neurosurgery |
| الوصف: | SOCS3, a feedback inhibitor of the JAK/STAT signal pathway, negatively regulates axonal regrowth and inflammation in the central nervous system (CNS). Here, we demonstrated a distinct role of SOCS3 in the injured spinal cord of the gecko following tail amputation. Severing the gecko spinal cord did not evoke an inflammatory cascade except for an injury-stimulated elevation of the granulocyte/macrophage colony-stimulating factor (GM-CSF) and interferon gamma (IFN-γ) cytokines. Simultaneously, the expression of SOCS3 was upregulated in microglia, and unexpectedly not in neurons. Enforced expression of SOCS3 was sufficient to suppress the GM-CSF/IFN-γ-driven inflammatory responses through its KIR domain by attenuating the activities of JAK1 and JAK2. SOCS3 was also linked to GM-CSF/IFN-γ-induced cross-tolerance. Transfection of adenovirus overexpressing SOCS3 in the injured cord resulted in a significant decrease of inflammatory cytokines. These results reveal a distinct role of SOCS3 in the regenerating spinal cord, and provide new hints for CNS repair in mammals. Electronic supplementary material The online version of this article (10.1007/s12264-020-00493-8) contains supplementary material, which is available to authorized users. |
| تدمد: | 1995-8218 1673-7067 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b4715e45e62f34809f007dcf17fefa7 https://doi.org/10.1007/s12264-020-00493-8 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8b4715e45e62f34809f007dcf17fefa7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19958218 16737067 |
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