Kardiale stereotaktische Strahlentherapie induziert eine Umprogrammierung des elektrischen Reizleitungssystems
| العنوان: | Kardiale stereotaktische Strahlentherapie induziert eine Umprogrammierung des elektrischen Reizleitungssystems |
|---|---|
| المؤلفون: | Oliver Blanck, Judit Boda-Heggemann, Stephan Hohmann, Felix Mehrhof, David Krug |
| المصدر: | Strahlentherapie Und Onkologie |
| بيانات النشر: | Springer Berlin Heidelberg, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Action Potentials, Dose-Response Relationship, Radiation, Heart, Endomyocardial Fibrosis, NAV1.5 Voltage-Gated Sodium Channel, Electrocardiography, Mice, Oncology, Gene Expression Regulation, Heart Conduction System, Heart Rate, Connexin 43, Tachycardia, Ventricular, Animals, Humans, Radiology, Nuclear Medicine and imaging, Female, Radiotherapy, Literatur Kommentiert, Signal Transduction |
| الوصف: | Cardiac radiotherapy (RT) may be effective in treating heart failure (HF) patients with refractory ventricular tachycardia (VT). The previously proposed mechanism of radiation-induced fibrosis does not explain the rapidity and magnitude with which VT reduction occurs clinically. Here, we demonstrate in hearts from RT patients that radiation does not achieve transmural fibrosis within the timeframe of VT reduction. Electrophysiologic assessment of irradiated murine hearts reveals a persistent supraphysiologic electrical phenotype, mediated by increases in Na |
| اللغة: | English |
| تدمد: | 1439-099X 0179-7158 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba1c47be458753a0c17df2a218a0a04 http://europepmc.org/articles/PMC8789705 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8ba1c47be458753a0c17df2a218a0a04 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 1439099X 01797158 |
|---|