أعرض في EDS

Pattern-recognition techniques with haplotype analysis in pharmacogenomics

التفاصيل البيبلوغرافية
العنوان: Pattern-recognition techniques with haplotype analysis in pharmacogenomics
المؤلفون: Eugene Lin, Kung-Hao Liang, Yuchi Hwang, Ellson Y Chen
المصدر: Pharmacogenomics. 8:75-83
بيانات النشر: Future Medicine Ltd, 2007.
سنة النشر: 2007
مصطلحات موضوعية: Genetic Markers, Pharmacology, Genetics, Linkage disequilibrium, Haplotype, Single-nucleotide polymorphism, Tag SNP, Biology, Polymorphism, Single Nucleotide, Linkage Disequilibrium, Pattern Recognition, Automated, SNP genotyping, Haplotypes, Pharmacogenetics, Pharmacogenomics, Animals, Humans, Molecular Medicine, Genetic association
الوصف: Single nucleotide polymorphisms (SNPs) can be used in clinical association studies to determine the contribution of genes to drug efficacy. However, it would be extremely inefficient to test all the 10 million common SNPs for an association study. Here we review haplotype analysis and pattern-recognition techniques to systematically select candidate SNPs for candidate-gene association studies in pharmacogenomics. First, we survey linkage disequilibrium methods to identify tag SNPs and explore the use of haplotypes as genetic markers that are correlated and associated with drug efficacy. Secondly, we investigate pattern-recognition algorithms and statistical analyses to assess drug efficacy based on SNPs and other factors. Finally, we study pattern-recognition approaches to evaluate the epistasis among genes and SNPs. These techniques may provide tools for clinical association studies and help find genes/SNPs involved in responses to therapeutic drugs or adverse drug reactions.
تدمد: 1744-8042
1462-2416
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba84e2374e2b40cdf89f34a5431ce7c
https://doi.org/10.2217/14622416.8.1.75
رقم الأكسشن: edsair.doi.dedup.....8ba84e2374e2b40cdf89f34a5431ce7c
قاعدة البيانات: OpenAIRE
الوصف
تدمد:17448042
14622416