Effects of exercise training on immunological factors in kidney transplant recipients; a randomized controlled trial
| العنوان: | Effects of exercise training on immunological factors in kidney transplant recipients; a randomized controlled trial |
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| المؤلفون: | Jamshid Roozbeh, Mohsen Salesi, Maryam Koushkie Jahromi, Meghdad Abdollahpour-Alitappeh, Mohammad Hossein Karimi, Sohrab Kazemi, Narges Jamshidian-Tehrani, Nazi Hemmati |
| المصدر: | Research in Sports Medicine. 30:80-91 |
| بيانات النشر: | Informa UK Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.medical_treatment, Physical Therapy, Sports Therapy and Rehabilitation, Kidney transplant, law.invention, Proinflammatory cytokine, 03 medical and health sciences, 0302 clinical medicine, Immune system, Randomized controlled trial, law, Internal medicine, Humans, Immunologic Factors, Medicine, Orthopedics and Sports Medicine, Exercise, business.industry, FOXP3, Resistance Training, 030229 sport sciences, Kidney Transplantation, Cytokine, Immunological Factors, Tumor necrosis factor alpha, business, 030217 neurology & neurosurgery |
| الوصف: | The purpose of this study was to investigate the effects of a 12 week exercise training on the immune system of kidney transplant recipients. 23 kidney transplant recipients were randomly divided into two groups including control (n = 10) and training (n =13) groups. The training groups participated in the training for 10 weeks (three days a week; each day 60-90 minutes). The control group performed no regular exercise during this time. The blood samples were taken before and after 12 weeks. ELISA and Real-time PCR were used to evaluate cytokine profiles, including TNF-a, IL-6, IL-4, IL-31 and IL-35 as well as T-bet, GATA-3, RORYt and FOXP3, respectively. Finally, the data were analyzed, using paired T-test. ELISA results showed decreased levels of TNF- α, increased levels of IL-6 and no significant differences in the IL-35, IL-31 and IL-4 levels in the training group in comparison to the control group. Gene expression profiles showed significantly increased expression of T-bet and no changes in the GATA-3, RORYt and FOXP3 levels. According to these results, a moderate exercise including aerobic and resistance training could inhibit inflammatory cytokines and have beneficial effects on the immune system, but this issue needs further research. |
| تدمد: | 1543-8635 1543-8627 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf3fa68444cf8e5a501dcff1a3558f0 https://doi.org/10.1080/15438627.2021.1906671 |
| رقم الأكسشن: | edsair.doi.dedup.....8bf3fa68444cf8e5a501dcff1a3558f0 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15438635 15438627 |
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