BEX2 is required for maintaining dormant cancer stem cell in hepatocellular carcinoma
| العنوان: | BEX2 is required for maintaining dormant cancer stem cell in hepatocellular carcinoma |
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| المؤلفون: | Yu Katayose, Jun Yasuda, Kazunori Yamaguchi, Daisuke Fukushi, Keiichi Tamai, Mai Mochizuki, Kazuhiro Murakami, Yuta Wakui, Kennichi Satoh, Kazuo Sugamura, Takayuki Kogure, Chikashi Shibata, Makoto Abue, Haruna Fujimori, Rie Shibuya-Takahashi, Yasuhiro Nakamura, Wataru Iwai, Takahiro Sugai |
| المصدر: | Cancer Science |
| بيانات النشر: | John Wiley and Sons Inc., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Cancer Research, cancer stem cell, Carcinoma, Hepatocellular, Antineoplastic Agents, Nerve Tissue Proteins, Biology, Cholangiocarcinoma, Mice, Cell, Molecular, and Stem Cell Biology, Cancer stem cell, Cell Line, Tumor, Spheroids, Cellular, medicine, BEX2, Animals, Humans, Gene Silencing, dormant, Aged, Cisplatin, Gene knockdown, Liver Neoplasms, General Medicine, Original Articles, hepatocellular carcinoma, Aldehyde Dehydrogenase, medicine.disease, Prognosis, Phenotype, digestive system diseases, Organoids, Oncology, Cell culture, Hepatocellular carcinoma, Cancer cell, Cancer research, Neoplastic Stem Cells, Original Article, Female, Stem cell, medicine.drug |
| الوصف: | Cancer stem cells (CSCs) are responsible for therapy resistance and share several properties with normal stem cells. Here, we show that brain‐expressed X‐linked gene 2 (BEX2), which is essential for dormant CSCs in cholangiocarcinoma, is highly expressed in human hepatocellular carcinoma (HCC) lesions compared with the adjacent normal lesions and that in 41 HCC cases the BEX2high expression group is correlated with a poor prognosis. BEX2 localizes to Ki67‐negative (nonproliferative) cancer cells in HCC tissues and is highly expressed in the dormant fraction of HCC cell lines. Knockdown of BEX2 attenuates CSC phenotypes, including sphere formation ability and aldefluor activity, and BEX2 overexpression enhances these phenotypes. Moreover, BEX2 knockdown increases cisplatin sensitivity, and BEX2 expression is induced by cisplatin treatment. Taken together, these data suggest that BEX2 induces dormant CSC properties and affects the prognosis of patients with HCC. BEX2 is essential for dormant cancer stem cell and affects patients’ prognosis in hepatocellular carcinoma. BEX2 could be a promising therapeutic target. |
| اللغة: | English |
| تدمد: | 1349-7006 1347-9032 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c43d19dd6dd3fe198755826decd1879 http://europepmc.org/articles/PMC8586677 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8c43d19dd6dd3fe198755826decd1879 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13497006 13479032 |
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