Diagnostic value of oncofetal miRNAs in cancers: A comprehensive analysis of circulating miRNAs in pan-cancers and UCB
| العنوان: | Diagnostic value of oncofetal miRNAs in cancers: A comprehensive analysis of circulating miRNAs in pan-cancers and UCB |
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| المؤلفون: | Xin Zhou, Xiangnan Geng, Yin Yin, Wei Zhu, Cheng Liu, Wenfang Cheng, Tiansong Xia, Xuan Zou, Cheng Zhang, Ping Liu |
| المصدر: | Cancer Biomarkers. 32:19-36 |
| بيانات النشر: | IOS Press, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Circulating mirnas, Cancer Research, Cancer detection, Umbilical cord, 03 medical and health sciences, 0302 clinical medicine, Antigens, Neoplasm, Neoplasms, microRNA, Biomarkers, Tumor, Genetics, medicine, Retrospective analysis, Humans, 030304 developmental biology, 0303 health sciences, Plasma samples, business.industry, Cancer, General Medicine, Fetal Blood, medicine.disease, Serum samples, MicroRNAs, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Cancer research, Female, business |
| الوصف: | BACKGROUND: Circulating miRNAs are promising biomarkers for detection of various cancers. As a “developmental” disorder, cancer showed great similarities with embryos. OBJECTIVE: A comprehensive analysis of circulating miRNAs in umbilical cord blood (UCB) and pan-cancers was conducted to identify circulating miRNAs with potential for cancer detection. METHODS: A total of 3831 cancer samples (2050 serum samples from 15 types of cancers and 1781 plasma samples from 13 types of cancers) and 248 UCB samples (120 serum and 128 plasma samples) with corresponding NCs from Chinese populations were analyzed via consistent experiment workflow with Exiqon panel followed by multiple-stage validation with qRT-PCR. RESULTS: Thirty-four serum and 32 plasma miRNAs were dysregulated in at least one type of cancer. Eighteen serum and 16 plasma miRNAs were related with embryos. Among them, 9 serum and 8 plasma miRNAs with consistent expression patterns between pan-cancers and UCB were identified as circulating oncofetal miRNAs. Retrospective analysis confirmed the diagnostic ability of circulating oncofetal miRNAs for specific cancers. And the oncofetal miRNAs were mainly up-regulated in tissues of pan-cancers. CONCLUSIONS: Our study might serve as bases for the potential application of the non-invasive biomarkers in the future clinical. |
| تدمد: | 1875-8592 1574-0153 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5f99bd35fe11f35f0c259ba7c46721 https://doi.org/10.3233/cbm-203085 |
| رقم الأكسشن: | edsair.doi.dedup.....8c5f99bd35fe11f35f0c259ba7c46721 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758592 15740153 |
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