Travel to Asia and traveller's diarrhoea with antibiotic treatment are independent risk factors for acquiring ciprofloxacin-resistant and extended spectrum β-lactamase-producing Enterobacteriaceae-a prospective cohort study
| العنوان: | Travel to Asia and traveller's diarrhoea with antibiotic treatment are independent risk factors for acquiring ciprofloxacin-resistant and extended spectrum β-lactamase-producing Enterobacteriaceae-a prospective cohort study |
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| المؤلفون: | Alex G. Koek, Ineke G. Stolte, T.J.W. van de Laar, Christina M. J. E. Vandenbroucke-Grauls, N. al Naiemi, E.A. Reuland, G.J.B. Sonder, A.P. van Dam, G.B. Linde |
| المساهمون: | Medical Microbiology and Infection Prevention, AII - Infectious diseases, Infectious diseases, Other departments |
| المصدر: | Clinical Microbiology and Infection, 22(8), 731.e1-7 Clinical microbiology and infection, 22(8), 731.e1-731.e7. Elsevier Limited Reuland, E A, Sonder, G J B, Stolte, I, Al Naiemi, N, Koek, A, Linde, G B, van de Laar, T J W, Vandenbroucke-Grauls, C M J E & van Dam, A P 2016, ' Travel to Asia and traveller's diarrhoea with antibiotic treatment are independent risk factors for acquiring ciprofloxacin-resistant and extended spectrum β-lactamase-producing Enterobacteriaceae-a prospective cohort study ', Clinical Microbiology and Infection, vol. 22, no. 8, pp. 731.e1-7 . https://doi.org/10.1016/j.cmi.2016.05.003 |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), Adult, Diarrhea, Male, Asia, medicine.drug_class, 030106 microbiology, Antibiotics, Microbial Sensitivity Tests, beta-Lactamases, Microbiology, Cohort Studies, 03 medical and health sciences, chemistry.chemical_compound, Enterobacteriaceae, Ciprofloxacin, Risk Factors, Drug Resistance, Bacterial, medicine, Prevalence, polycyclic compounds, Humans, Prospective Studies, Risk factor, Etest, Travel, biology, Enterobacteriaceae Infections, General Medicine, Middle Aged, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, bacterial infections and mycoses, Anti-Bacterial Agents, Infectious Diseases, chemistry, bacteria, Gentamicin, Female, medicine.symptom, Ertapenem, human activities, medicine.drug |
| الوصف: | Travel to (sub)tropical countries is a well-known risk factor for acquiring resistant bacterial strains, which is especially of significance for travellers from countries with low resistance rates. In this study we investigated the rate of and risk factors for travel-related acquisition of extended spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E), ciprofloxacin-resistant Enterobacteriaceae (CIPR-E) and carbapenem-resistant Enterobacteriaceae. Data before and after travel were collected from 445 participants. Swabs were cultured with an enrichment broth and sub-cultured on selective agar plates for ESBL detection, and on plates with a ciprofloxacin disc. ESBL production was confirmed with the double-disc synergy test. Species identification and susceptibility testing were performed with the Vitek-2 system. All isolates were subjected to ertapenem Etest. ESBL and carbapenemase genes were characterized by PCR and sequencing. Twenty-seven out of 445 travellers (6.1%) already had ESBL-producing strains and 45 of 445 (10.1%) travellers had strains resistant to ciprofloxacin before travel. Ninety-eight out of 418 (23.4%) travellers acquired ESBL-E and 130 of 400 (32.5%) travellers acquired a ciprofloxacin-resistant strain. Of the 98 ESBL-E, predominantly Escherichia coli and predominantly blaCTX-M-15, 56% (55/98) were resistant to gentamicin, ciprofloxacin and co-trimoxazole. Multivariate analysis showed that Asia was a high-risk area for ESBL-E as well as CIPR-E acquisition. Travellers with diarrhoea combined with antimicrobial use were significantly at higher risk for acquisition of resistant strains. Only one carbapenemase-producing isolate was acquired, isolated from a participant after visiting Egypt. In conclusion, travelling to Asia and diarrhoea combined with antimicrobial use are important risk factors for acquiring ESBL-E and CIPR-E. |
| اللغة: | English |
| تدمد: | 1198-743X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c72105073233749fbfabfb19d4bd329 https://research.vumc.nl/en/publications/e8772c64-097b-4762-b41a-30c0446e05cf |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8c72105073233749fbfabfb19d4bd329 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1198743X |
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