Dysbiosis Disrupts Gut Immune Homeostasis and Promotes Gastric Diseases
| العنوان: | Dysbiosis Disrupts Gut Immune Homeostasis and Promotes Gastric Diseases |
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| المؤلفون: | Chhavi Goel, Prashant Kumar, Hridayesh Prakash, Anil Kumar, Sandhya Singh, Devinder Toor, G Karthikeyan, Mishi Kaushal Wsson, Naveen Kumar Kaushik |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 20, Iss 10, p 2432 (2019) |
| بيانات النشر: | MDPI, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Antibiotics, Review, Gut flora, lcsh:Chemistry, 0302 clinical medicine, immune epigenetics, Homeostasis, Receptor, Hypoxia, lcsh:QH301-705.5, Spectroscopy, education.field_of_study, biology, Toll-Like Receptors, General Medicine, Gastric Diseases, Computer Science Applications, Anti-Bacterial Agents, 030220 oncology & carcinogenesis, medicine.drug_class, Population, TLR mimicry, Stomach Diseases, Antineoplastic Agents, Catalysis, Autoimmune Diseases, Inorganic Chemistry, 03 medical and health sciences, Immune system, medicine, Animals, Humans, Epigenetics, Physical and Theoretical Chemistry, education, Molecular Biology, Inflammation, gut microbiota, Host Microbial Interactions, Macrophages, Organic Chemistry, medicine.disease, biology.organism_classification, Diet, Gastrointestinal Microbiome, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, sterile inflammation, Immunology, Dysbiosis, metabolism |
| الوصف: | Perturbation in the microbial population/colony index has harmful consequences on human health. Both biological and social factors influence the composition of the gut microbiota and also promote gastric diseases. Changes in the gut microbiota manifest in disease progression owing to epigenetic modification in the host, which in turn influences differentiation and function of immune cells adversely. Uncontrolled use of antibiotics, chemotherapeutic drugs, and any change in the diet pattern usually contribute to the changes in the colony index of sensitive strains known to release microbial content in the tissue micromilieu. Ligands released from dying microbes induce Toll-like receptor (TLR) mimicry, skew hypoxia, and cause sterile inflammation, which further contributes to the severity of inflammatory, autoimmune, and tumorous diseases. The major aim and scope of this review is both to discuss various modalities/interventions across the globe and to utilize microbiota-based therapeutic approaches for mitigating the disease burden. |
| اللغة: | English |
| تدمد: | 1422-0067 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c798f4f66c06007b4fdc1dd809c9175 http://europepmc.org/articles/PMC6567003 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8c798f4f66c06007b4fdc1dd809c9175 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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