Otologic Manifestations of Eosinophilic Granulomatosis With Polyangiitis: A Systematic Review
| العنوان: | Otologic Manifestations of Eosinophilic Granulomatosis With Polyangiitis: A Systematic Review |
|---|---|
| المؤلفون: | Gregory L. Barinsky, Seilesh Babu, Brian E. Benson, Tiffany Chen, Peter F. Svider, Peter E. Ashman, Dennis I. Bojrab |
| المصدر: | Otology & Neurotology. 42:e380-e387 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.medical_treatment, Churg-Strauss Syndrome, Cochrane Library, Myringotomy, 03 medical and health sciences, 0302 clinical medicine, Eosinophilic, medicine, Humans, Eosinophilia, 030223 otorhinolaryngology, Asthma, Otitis Media with Effusion, business.industry, Granulomatosis with Polyangiitis, Middle Aged, medicine.disease, Middle Ear Ventilation, Dermatology, Sensory Systems, Otitis Media, Otitis, Otorhinolaryngology, Effusion, Neurology (clinical), medicine.symptom, Granulomatosis with polyangiitis, business, 030217 neurology & neurosurgery |
| الوصف: | OBJECTIVE To perform a systematic review of the diagnosis, treatment, and management of patients with otologic manifestations of eosinophilic granulomatosis with polyangiitis. DATABASES REVIEWED PubMed, Embase, Cochrane. METHODS A systematic search for relevant published literature in PubMed, Cochrane Library, and EMBASE databases was done. Data was collected on demographics, otologic manifestations, specific diagnostic criteria fulfilled, common clinical, and imaging findings as well as medical and surgical treatments received. RESULTS Fifteen articles encompassing 219 patients met inclusion criteria including 8 case reports and 7 case series. The mean age was 52.8 (range of 24-70). The most common otologic presenting symptoms were hearing loss (76%), otitis media with effusion (44%), vertigo (22%), tinnitus (21%), and chronic otitis media (20%). The most common diagnostic criteria observed in these patients were paranasal sinus abnormalities (75%), asthma (66%), and eosinophilia >10% (44%). The most common treatment was systemic steroids (66%), followed by surgery (52%), with myringotomy with tube insertion (M&T) (32%) and endoscopic sinus surgery (21%) being the most prevalent. Thirty-four percent of patients received an immunosuppressive agent. Successful treatments included systemic steroids (23%), surgical modalities (13%) with M&T being the most common (7%), topical nasal steroids (12%), and cyclophosphamide (10%). CONCLUSION Hearing loss and a middle ear effusion are the most common presenting otologic manifestations of eosinophilic granulomatosis with polyangiitis. Sinonasal disease was more prevalent in patients with otologic manifestations. Primary treatment consists of systemic steroids and immunomodulation. M&T, endoscopic sinus surgery, and local steroid administration can be adjunctive measures to alleviate local disease.Level of Evidence: Level 1. |
| تدمد: | 1537-4505 1531-7129 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8ad3644ce921124c44f616defac34d https://doi.org/10.1097/mao.0000000000003024 |
| رقم الأكسشن: | edsair.doi.dedup.....8c8ad3644ce921124c44f616defac34d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15374505 15317129 |
|---|