A Meta-analysis of Xiaoyin Granules Combined with Acitretin Capsule in the Treatment of Psoriasis Vulgaris
| العنوان: | A Meta-analysis of Xiaoyin Granules Combined with Acitretin Capsule in the Treatment of Psoriasis Vulgaris |
|---|---|
| المؤلفون: | Aiai Geng, Tianli Pei, Xueyi Zhao, Bo Jia |
| المصدر: | Computational and Mathematical Methods in Medicine. 2022:1-14 |
| بيانات النشر: | Hindawi Limited, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Article Subject, General Immunology and Microbiology, Applied Mathematics, Modeling and Simulation, Chronic Disease, Humans, Psoriasis, General Medicine, Combined Modality Therapy, Acitretin, General Biochemistry, Genetics and Molecular Biology, Drugs, Chinese Herbal |
| الوصف: | Background. Psoriasis is a chronic noncommunicable dermatological condition, and psoriasis vulgaris is the most common phenotype. Acitretin is the most widely used systemic retinoid in the treatment of psoriasis. This review evaluates the clinical therapeutic effects of Xiaoyin granule, a Chinese herbal medicine, combined with acitretin capsule in the treatment of psoriasis vulgaris. Methods. Six databases including PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), Wan Fang, and China Biology Medicine disc (CBM) were searched for published studies on Xiaoyin granule and/or acitretin capsule in psoriasis vulgaris. The Cochrane Collaboration risk-of-bias instrument was used to assess the quality of the included RCTs. STATA 14.0 was used to conduct the statistical analysis. Results. Twenty-eight trials with 3281 patients were included in this meta-analysis. The results of this study show that the combined treatment of Xiaoyin granule and acitretin capsule could improve the total effective rate (TER) and cure rate (CR) when compared with acitretin capsule (TER: RR = 1.15 , 95% CI (1.10, 1.21); CR: RR = 1.8 , 95% CI (1.62, 2.00)) or Xiaoyin granule (TER: RR = 1.24 , 95% CI (1.11, 1.39); CR: RR = 1.75 , 95% CI (1.54, 1.98)) alone. The combined therapy could decrease the PASI score (mean difference = − 1.45 , 95% CI (-2.09, -0.80)) and inhibit inflammation (IL-10: mean difference = 1.16 , 95% CI (0.94, 1.38); IL-17: mean difference = − 2.06 , 95% CI (-2.60, -1.51)) in psoriasis vulgaris patients. Conclusions. The combination of Xiaoyin granule and acitretin capsules could be a novel therapeutic strategy in the treatment of psoriasis vulgaris. However, the quality of trials in this study limited the conclusion, and more high-quality RCTs are needed for further evaluation. |
| وصف الملف: | text/xhtml |
| تدمد: | 1748-6718 1748-670X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c9086bf7b5c15aa035987885fbc8120 https://doi.org/10.1155/2022/7360975 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8c9086bf7b5c15aa035987885fbc8120 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17486718 1748670X |
|---|