Treatment planning comparison of volumetric modulated arc therapy employing a dual-layer stacked multi-leaf collimator and helical tomotherapy for cervix uteri
| العنوان: | Treatment planning comparison of volumetric modulated arc therapy employing a dual-layer stacked multi-leaf collimator and helical tomotherapy for cervix uteri |
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| المؤلفون: | Luca Cozzi, S. Panda, Jai Prakash Agarwal, Antonella Fogliata, Supriya Chopra, Jamema Swamidas, Akshay Mangaj, P.A. Kupelian |
| المصدر: | Radiation Oncology, Vol 15, Iss 1, Pp 1-12 (2020) Radiation Oncology (London, England) |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Organs at Risk, lcsh:Medical physics. Medical radiology. Nuclear medicine, lcsh:R895-920, medicine.medical_treatment, Uterine Cervical Neoplasms, Dual-layer MLC, VMAT, lcsh:RC254-282, Tomotherapy, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Helical Tomotherapy, Radiation Injuries, Radiometry, Radiation treatment planning, Cervix, business.industry, Research, Radiotherapy Planning, Computer-Assisted, Halcyon, Dual layer, Radiotherapy Dosage, Multi leaf collimator, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Volumetric modulated arc therapy, Cervix uteri, Radiation therapy, Clinical trial, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Female, Radiotherapy, Intensity-Modulated, Nuclear medicine, business, RapidArc |
| الوصف: | Purpose To ascertain the dosimetric performance of a new delivery system (the Halcyon system, H) equipped with dual-layer stacked multi-leaf collimator (MLC) for risk-adapted targets in cervix uteri cancer patients compared to another ring-based system in clinical operation (Helical Tomotherapy, HT). Methods Twenty patients were retrospectively included in a treatment planning study (10 with positive lymph nodes and 10 without). The dose prescription (45Gy to the primary tumour volume and a simultaneously integrated boost up to 55Gy for the positive patients) and the clinical planning objectives were defined consistently as recommended by an ongoing multicentric clinical trial. Halcyon plans were optimised for the volumetric modulated arc therapy. The plan comparison was performed employing the quantitative analysis of the dose-volume histograms. Results The coverage of the primary and nodal target volumes was comparable for both techniques and both subsets of patients. The primary planning target volume (PTV) receiving at least 95% of the prescription isodose ranged from 97.2 ± 1.1% (node-negative) to 99.1 ± 1.2% (node-positive) for H and from 96.5 ± 1.9% (node-negative) to 98.3 ± 0.9% (node-positive) for HT. The uncertainty is expressed at one standard deviation from the cohort of patient per each group. For the nodal clinical target volumes, the dose received by 98% of the planning target volume ranged 55.5 ± 0.1 to 56.0 ± 0.8Gy for H and HT, respectively. The only significant and potentially relevant differences were observed for the bowels. In this case, V40Gy resulted 226.3 ± 35.9 and 186.9 ± 115.9 cm3 for the node-positive and node-negative patients respectively for Halcyon. The corresponding findings for HT were: 258.9 ± 60.5 and 224.9 ± 102.2 cm3. On the contrary, V15Gy resulted 1279.7 ± 296.5 and 1557.2 ± 359.9 cm3 for HT and H respectively for node-positive and 1010.8 ± 320.9 versus 1203.8 ± 332.8 cm3 for node-negative. Conclusion This retrospective treatment planning study, based on the dose constraints derived from the Embrace II study protocol, suggested the essential equivalence between Halcyon based and Helical Tomotherapy based plans for the intensity-modulated rotational treatment of cervix uteri cancer. Different levels of sparing were observed for the bowels with H better protecting in the high-dose region and HT in the mid-low dose regions. The clinical impact of these differences should be further addressed. |
| تدمد: | 1748-717X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb0bc0f8e9fbc6f86c572a0f9a95170 https://doi.org/10.1186/s13014-020-1473-z |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8cb0bc0f8e9fbc6f86c572a0f9a95170 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 1748717X |
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