Human marginal zone B cell development from early T2 progenitors
| العنوان: | Human marginal zone B cell development from early T2 progenitors |
|---|---|
| المؤلفون: | William Guesdon, Michael J. Pitcher, Yuan Zhao, Cristina Lebrero-Fernández, Richard Groves, Wayel Jassem, Michelle Kleeman, Susanne Heck, Yogesh Kamra, David J. Fear, David D'Cruz, Richard Ellis, Susan D. John, Ulrich D. Kadolsky, Nedyalko Petrov, Pawan Dhami, Jeremy D. Sanderson, Thomas J Tull, Mats Bemark, Jacqueline Hy Siu, Jo Spencer, Michael D. Robson |
| المساهمون: | Siu, Jacqueline [0000-0001-5181-407X], Apollo - University of Cambridge Repository |
| المصدر: | Spencer, J, Tull, T, Pitcher, M, Guesdon, W, Siu, J HY, Lebraro-Fernandez, C, Zhao, Y, Petrov, N, Heck, S, Ellis, R, Dhami, P, kadolsky, U, Kleeman, M, Kamra, Y, Fear, D, John, S, Jassem, W, Groves, R, Sanderson, J D, Robson, M, D’Cruz, D & Bemark, M 2021, ' Human marginal zone B cell development from early T2 progenitors ', Journal of Experimental Medicine, vol. 218, no. 4, e20202001 . https://doi.org/10.1084/jem.20202001 The Journal of Experimental Medicine |
| بيانات النشر: | Cold Spring Harbor Laboratory, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Integrin beta Chains, Autoimmunity, Blood Donors, Technical Advances and Resources, Transcriptome, 0302 clinical medicine, immune system diseases, Marginal zone B-cell, Immunology and Allergy, skin and connective tissue diseases, Cells, Cultured, B-Lymphocytes, digestive, oral, and skin physiology, Interleukin-4 Receptor alpha Subunit, Cell Differentiation, Mucosal Immunology, Middle Aged, Marginal zone, Lupus Nephritis, Cell biology, Phenotype, Lymphatic system, medicine.anatomical_structure, Female, Single-Cell Analysis, Adult, Lymphoid Tissue, Immunology, Naive B cell, Biology, Young Adult, 03 medical and health sciences, medicine, Humans, Cell Lineage, Progenitor cell, Interleukin 4, Aged, Sequence Analysis, RNA, Precursor Cells, B-Lymphoid, Gastrointestinal Tract, 030104 developmental biology, Immunoglobulin M, Case-Control Studies, biology.protein, Bone marrow, 030215 immunology, Homing (hematopoietic) |
| الوصف: | This study identifies a developmental trajectory from human IgMhi gut homing transitional 2 cells to marginal zone B cells, all stages of which are affected in patients with severe systemic lupus erythematosus. B cells emerge from the bone marrow as transitional (TS) B cells that differentiate through T1, T2, and T3 stages to become naive B cells. We have identified a bifurcation of human B cell maturation from the T1 stage forming IgMhi and IgMlo developmental trajectories. IgMhi T2 cells have higher expression of α4β7 integrin and lower expression of IL-4 receptor (IL4R) compared with the IgMlo branch and are selectively recruited into gut-associated lymphoid tissue. IgMhi T2 cells also share transcriptomic features with marginal zone B cells (MZBs). Lineage progression from T1 cells to MZBs via an IgMhi trajectory is identified by pseudotime analysis of scRNA-sequencing data. Reduced frequency of IgMhi gut-homing T2 cells is observed in severe SLE and is associated with reduction of MZBs and their putative IgMhi precursors. The collapse of the gut-associated MZB maturational axis in severe SLE affirms its existence in health. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb8c2c762c335e87f1bb70f46e6047e https://doi.org/10.1101/2020.09.24.311498 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8cb8c2c762c335e87f1bb70f46e6047e |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |