Thrombus Structural Composition in Cardiovascular Disease
| العنوان: | Thrombus Structural Composition in Cardiovascular Disease |
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| المؤلفون: | Yu Shi, Cédric Duval, Ghadir Alkarithi, Robert A. S. Ariëns, Fraser L. Macrae |
| المصدر: | Arteriosclerosis, Thrombosis, and Vascular Biology |
| بيانات النشر: | Lippincott Williams & Wilkins, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Blood Platelets, Pathology, medicine.medical_specialty, Erythrocytes, 030204 cardiovascular system & hematology, Fibrin, Brief Review, blood vessels, 03 medical and health sciences, 0302 clinical medicine, medicine, Leukocytes, Animals, Humans, Platelet, Myocardial infarction, cardiovascular diseases, Thrombus, Blood Coagulation, biology, business.industry, Thrombosis, Blood flow, Neutrophil extracellular traps, medicine.disease, Red blood cell, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, myocardial infarction, Cholesterol, thrombectomy, biology.protein, cardiovascular system, Cardiology and Cardiovascular Medicine, business, circulatory and respiratory physiology |
| الوصف: | Thrombosis is a major complication of cardiovascular disease, leading to myocardial infarction, acute ischemic stroke, or venous thromboembolism. Thrombosis occurs when a thrombus forms inside blood vessels disrupting blood flow. Developments in thrombectomy to remove thrombi from vessels have provided new opportunities to study thrombus composition which may help to understand mechanisms of disease and underpin improvements in treatments. We aimed to review thrombus compositions, roles of components in thrombus formation and stability, and methods to investigate thrombi. Also, we summarize studies on thrombus structure obtained from cardiovascular patients and animal models. Thrombi are composed of fibrin, red blood cells, platelets, leukocytes, and neutrophil extracellular traps. These components have been analyzed by several techniques, including scanning electron microscopy, laser scanning confocal microscopy, histochemistry, and immunohistochemistry; however, each technique has advantages and limitations. Thrombi are heterogenous in composition, but overall, thrombi obtained from myocardial infarction are composed of mainly fibrin and other components, including platelets, red blood cells, leukocytes, and cholesterol crystals. Thrombi from patients with acute ischemic stroke are characterized by red blood cell- and platelet-rich regions. Thrombi from patients with venous thromboembolism contain mainly red blood cells and fibrin with some platelets and leukocytes. Thrombus composition from patients with myocardial infarction is influenced by ischemic time. Animal thrombosis models are crucial to gain further mechanistic information about thrombosis and thrombus structure, with thrombi being similar in composition compared with those from patients. Further studies on thrombus composition and function are key to improve treatment and clinical outcome of thrombosis. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1524-4636 1079-5642 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc7ddd0a50cb381335064e30cd3c1c4 http://europepmc.org/articles/PMC8384252 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8cc7ddd0a50cb381335064e30cd3c1c4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244636 10795642 |
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