Dysfunction of the cyclo-oxygenase pathway in the foetoplacental circulation in Type 1 diabetes mellitus
| العنوان: | Dysfunction of the cyclo-oxygenase pathway in the foetoplacental circulation in Type 1 diabetes mellitus |
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| المؤلفون: | Alfons C. Wouterse, Paul Smits, L.D. Elving, Frans G. M. Russel, Eric A.P. Steegers, Tanya M. Bisseling |
| المساهمون: | Obstetrics & Gynecology |
| المصدر: | Diabetic Medicine, 22(4), 503-506. Wiley-Blackwell Publishing Ltd Diabetic Medicine, 22, 503-6 Diabetic Medicine, 22, 4, pp. 503-6 |
| بيانات النشر: | Wiley, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Endothelium, Endocrinology, Diabetes and Metabolism, Indomethacin, Pregnancy in Diabetics, Membrane transport and intracellular motility [NCMLS 5], Blood Pressure, Vasodilation, Vascular medicine and diabetes [UMCN 2.2], In Vitro Techniques, Endocrinology, SDG 3 - Good Health and Well-being, Indometacin, Pregnancy, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Cyclooxygenase Inhibitors, Placental Circulation, Renal disorder [IGMD 9], Type 1 diabetes, Cardiovascular diseases [NCEBP 14], biology, Endocrinology and reproduction [UMCN 5.2], business.industry, Effective Hospital Care [EBP 2], medicine.disease, Renal disorders [UMCN 5.4], Diabetes Mellitus, Type 1, Blood pressure, medicine.anatomical_structure, Prostaglandin-Endoperoxide Synthases, Vasoconstriction, Enzyme inhibitor, biology.protein, Female, Cyclo-oxygenase, business, Signal Transduction, medicine.drug |
| الوصف: | Contains fulltext : 48788.pdf (Publisher’s version ) (Closed access) AIM: In diabetes, perinatal morbidity is significantly increased. This may partly be related to functional changes in the foetoplacental vascular bed. In diabetes models, a defect in the cyclo-oxygenase pathway is a common observation. Therefore, we hypothesized that the human foetoplacental circulation of diabetic patients is characterized by dysfunction of the cyclo-oxygenase pathway, as well. METHODS: We performed ex-vivo perfusions of isolated placental cotyledons from healthy women (n = 14) and from patients with Type 1 diabetes (n = 9). The contribution of cyclo-oxygenase products to foetoplacental vascular tone was quantified by measuring the response to the cyclo-oxygenase inhibitor indomethacin. RESULTS: Baseline foetoplacental arterial pressure was comparable between controls and diabetic women (mean +/- sem, 21.7 +/- 1.2 vs. 24.4 +/- 2.0 mmHg). Maximum foetoplacental arterial pressure at highest dose of indomethacin was 32.8 +/- 3.0 mmHg in controls vs. 27.3 +/- 2.3 mmHg in diabetic women. The indomethacin-induced increase in pressure was reduced in diabetes (2.9 +/- 0.7 vs. 11.2 +/- 2.4 mmHg in controls, P = 0.01). CONCLUSIONS: Under baseline conditions, the net effect of all cyclo-oxygenase products in the foetoplacental vascular bed is vasodilation. In diabetes, this vasodilator effect seems significantly impaired. |
| وصف الملف: | application/pdf |
| تدمد: | 1464-5491 0742-3071 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d02c30f785bee4cb636a3070dd76a8e https://doi.org/10.1111/j.1464-5491.2005.01437.x |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....8d02c30f785bee4cb636a3070dd76a8e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14645491 07423071 |
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