Detection of collagens in brain tumors based on FTIR imaging and chemometrics
| العنوان: | Detection of collagens in brain tumors based on FTIR imaging and chemometrics |
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| المؤلفون: | Razia Noreen, Raphael Pineau, Yeukuang Hwu, Michel Moenner, Maylis Delugin, Cyril Petibois, Chia-Chi Chien, Seydou Yao |
| المساهمون: | Noreen, Razia, Chien, Chia-Chi, Delugin, Maylis, Yao, Sedou, Pineau, Raphael, Hwu, Y, Moenner, Michel, Petibois, Cyril |
| المصدر: | Analytical and Bioanalytical Chemistry. 401:845-852 |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Pathology, Analytical chemistry, Infrared spectroscopy, Brain tissue, Biochemistry, Protein Structure, Secondary, Analytical Chemistry, Chemometrics, Mice, Cell Line, Tumor, Glioma, Spectroscopy, Fourier Transform Infrared, medicine, Animals, Fourier transform infrared spectroscopy, Protein secondary structure, Brain Neoplasms, Chemistry, chemometrics, medicine.disease, Radiography, IR spectroscopy, statistics, collagen types, Histopathology, Collagen, Factorial analysis |
| الوصف: | Fourier transform infrared (FTIR) imaging has been used as a molecular histopathology tool on brain tissue sections after intracranial implantation and development of glioma tumors. Healthy brain tissue (contralateral lobe) as well as solid and diffuse tumor tissues were compared for their collagen contents. IR spectra were extracted from IR images for determining the secondary structure of protein contents and compared to pure product spectra of collagens (types I, III, IV, V, and VI). Multivariate statistical analyses of variance and correspondence factorial analysis were performed to differentiate healthy and tumor brain tissues as well as their classification according to their secondary structure profiles. Secondary structure profiles revealed that no collagen was present in healthy tissues; they are also significantly different from solid and diffuse tumors (p |
| تدمد: | 1618-2650 1618-2642 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0b5ca2b19bbbc861bb1b15625aa920 https://doi.org/10.1007/s00216-011-4899-1 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....8d0b5ca2b19bbbc861bb1b15625aa920 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 16182650 16182642 |
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