Regulation of transforming growth factor is involved in the efficacy of combined 5-fluorouracil and interferon alpha-2b therapy of advanced hepatocellular carcinoma
| العنوان: | Regulation of transforming growth factor is involved in the efficacy of combined 5-fluorouracil and interferon alpha-2b therapy of advanced hepatocellular carcinoma |
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| المؤلفون: | Kazuhiro Kasai, Kazuyuki Suzuki, Yasuhiro Takikawa, Youhei Okada, Ting Wang |
| المصدر: | Cell Death Discovery Cell Death Discovery, Vol 4, Iss 1, Pp 1-10 (2018) |
| بيانات النشر: | Nature Publishing Group UK, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, MAPK/ERK pathway, Cancer Research, Cell signaling, Combination therapy, lcsh:Cytology, Chemistry, Kinase, Immunology, Alpha interferon, Cell Biology, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Article, Hep G2, 03 medical and health sciences, Cellular and Molecular Neuroscience, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, lcsh:QH573-671, Transforming growth factor |
| الوصف: | Transforming growth factor-beta (TGF-β) is critical in cancer cell invasion and metastasis. The effects of a treatment that targets TGF-β using the combination of interferon alpha (IFNα)-2b and 5-fluorouracil (5-FU) are unknown. Here, we show that the serum levels of TGF-β1 prior to the therapy correlate with increased maximum tumor diameter, which is significantly (p |
| اللغة: | English |
| تدمد: | 2058-7716 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d380232a78b059fd62c59ceb3dcfdd2 http://europepmc.org/articles/PMC5849890 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8d380232a78b059fd62c59ceb3dcfdd2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20587716 |
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