Synthesis of new N ‐(3‐oxo‐1‐thia‐4‐azaspiro[4.5]decan‐4‐yl)pyridine‐3‐carboxamide derivatives and evaluation of their anti‐influenza virus and antitubercular activities
| العنوان: | Synthesis of new N ‐(3‐oxo‐1‐thia‐4‐azaspiro[4.5]decan‐4‐yl)pyridine‐3‐carboxamide derivatives and evaluation of their anti‐influenza virus and antitubercular activities |
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| المؤلفون: | Gökçe Cihan‑Üstündağ, Çiğdem Acar, Lieve Naesens, Gonca Erköse‑Genç, Dilek Şatana |
| المصدر: | Archiv der Pharmazie. 355:2200224 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Structure-Activity Relationship, Influenza A Virus, H1N1 Subtype, Pyridines, Influenza A Virus, H3N2 Subtype, Drug Discovery, Antitubercular Agents, Isoniazid, Pharmaceutical Science, Microbial Sensitivity Tests, Antiviral Agents |
| الوصف: | We here report the synthesis, structural characterization, and evaluation of the antiviral and antitubercular activities of a novel series of hybrid spirothiazolidinone derivatives (2a-f and 3a-f) containing the nicotinohydrazide moiety, which is an isomer form of the approved antitubercular drug isoniazid. When evaluated for activity against influenza A/H1N1, A/H3N2, and B viruses, three of the new compounds proved to possess specific antiviral activity against the influenza A/H3N2 virus. The most active analog 3a, bearing a 2,8-dimethyl group at the spiro ring, displayed an antiviral EC |
| تدمد: | 1521-4184 0365-6233 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5f6e308f12b7a769e107c82468f09e https://doi.org/10.1002/ardp.202200224 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....8d5f6e308f12b7a769e107c82468f09e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15214184 03656233 |
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