Similar synapse elimination motifs at successive relays in the same efferent pathway during development in mice
| العنوان: | Similar synapse elimination motifs at successive relays in the same efferent pathway during development in mice |
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| المؤلفون: | Shlomo Tsuriel, Shu-Hsien Sheu, Juan Carlos Tapia, Jeff W. Lichtman |
| المصدر: | eLife eLife, Vol 6 (2017) |
| بيانات النشر: | eLife Sciences Publications, Ltd, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Nervous system, peripheral ganglia, Mouse, Synaptic pruning, Gene Expression, Acinar Cells, parasympathetic nerves, Synapse, Parasympathetic nervous system, Mice, Postsynaptic potential, Genes, Reporter, Image Processing, Computer-Assisted, Biology (General), Neurons, Structural organization, Neuronal Plasticity, General Neuroscience, Optical Imaging, General Medicine, Anatomy, synaptic competition, medicine.anatomical_structure, Medicine, Fluorescein-5-isothiocyanate, Research Article, QH301-705.5, Science, Green Fluorescent Proteins, Submandibular Gland, Mice, Transgenic, Biology, Efferent Pathways, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Bacterial Proteins, Parasympathetic Nervous System, medicine, Animals, Efferent Pathway, General Immunology and Microbiology, Luminescent Proteins, 030104 developmental biology, Animals, Newborn, Synapses, Cholinergic, Thy-1 Antigens, synapse elimination, Neuroscience, Biomarkers |
| الوصف: | In many parts of the nervous system, signals pass across multiple synaptic relays on their way to a destination, but little is known about how these relays form and the function they serve. To get some insight into this question we ask how the connectivity patterns are organized at two successive synaptic relays in a simple, cholinergic efferent pathway. We found that the organization at successive relays in the parasympathetic nervous system strongly resemble each other despite the different embryological origin and physiological properties of the pre- and postsynaptic cells. Additionally, we found a similar developmental synaptic pruning and elaboration strategy is used at both sites to generate their adult organizations. The striking parallels in adult innervation and developmental mechanisms at the relays argue that a general strategy is in operation. We discuss why from a functional standpoint this structural organization may amplify central signals while at the same time maintaining positional targeting. DOI: http://dx.doi.org/10.7554/eLife.23193.001 |
| اللغة: | English |
| تدمد: | 2050-084X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d80df213223ddde217307e64248d67c http://europepmc.org/articles/PMC5315461 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8d80df213223ddde217307e64248d67c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2050084X |
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