Material approaches to active tissue mechanics
| العنوان: | Material approaches to active tissue mechanics |
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| المؤلفون: | Delphine Delacour, Wang Xi, Chwee Teck Lim, Thuan Beng Saw, Benoit Ladoux |
| المساهمون: | College of Engineering, Heilongjiang Bayi Agricultural University, Mechanobiology Institute [Singapore] (MBI), National University of Singapore (NUS), Department of cell biology and cell pathology, University of Marburg |
| المصدر: | Nature Reviews Materials Nature Reviews Materials, Nature Publishing Group, 2019, 4 (1), pp.23-44. ⟨10.1038/s41578-018-0066-z⟩ |
| بيانات النشر: | HAL CCSD, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio], [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], Morphogenesis, Motility, Cancer metastasis, 02 engineering and technology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, 010402 general chemistry, 01 natural sciences, Biomaterials, Molecular level, Materials Chemistry, medicine, Tissue mechanics, [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, ComputingMilieux_MISCELLANEOUS, Tissue level, 021001 nanoscience & nanotechnology, Epithelium, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Active matter, Cell biology, medicine.anatomical_structure, 0210 nano-technology, Energy (miscellaneous) |
| الوصف: | Communities of epithelial cells communicate through intercellular interactions, allowing them to coordinate their motility, which plays a key role in homeostasis, morphogenesis and cancer metastasis. Each cell in the epithelium is a constitutive energy-consuming agent, which can generate forces and interact with other cells through cell–cell junctions. Forces applied through external stimuli or endogenous cellular events are balanced by the cells within the epithelium, resulting in the adjustment of internal tissue contractile stresses and tissue reorganization. Materials science and microengineering techniques can be combined to create controllable environments to study epithelial movement and mechanics. By modulating the cell–material interface and by applying principles of active matter, key aspects of epithelial dynamics and mechanosensing mechanisms can be investigated. In this Review, we discuss epithelial tissues as active materials with particular rheological properties and active behaviours at different length scales. We highlight 2D and 3D materials for the study of epithelial dynamics and summarize key methods for the probing of epithelial mechanics. Tissue responses to mechanical stimuli are examined from the molecular level to the tissue level, and the effects of the shape, architecture and stiffness of the microenvironment are discussed. The dynamics of epithelial tissues play a key role in tissue organization, both in health and disease. In this Review, the authors discuss materials and techniques for the study of epithelial movement and mechanics and investigate epithelia as active matter from a theoretical and experimental perspective. |
| اللغة: | English |
| تدمد: | 2058-8437 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8e2a50cb7712a5307e3b72ab636295 https://hal.archives-ouvertes.fr/hal-02348678 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....8d8e2a50cb7712a5307e3b72ab636295 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 20588437 |
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