Uterine Preservation Treatments in Sarcomas: Oncological Problems and Reproductive Results: A Systematic Review
| العنوان: | Uterine Preservation Treatments in Sarcomas: Oncological Problems and Reproductive Results: A Systematic Review |
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| المؤلفون: | Linda Cipriani, Pierandrea De Iaco, Maria Dirodi, Alessandra Palma, Anna Myriam Perrone, Margherita Nannini, Eugenia De Crescenzo, Eleonora Porcu, Giuseppe Damiano, Giulia Dondi, Alessio G. Morganti, Maria Abbondanza Pantaleo, Martina Ferioli, Gloria Ravegnini, Antonio De Leo |
| المساهمون: | Dondi G., Porcu E., De Palma A., Damiano G., De Crescenzo E., Cipriani L., Dirodi M., Ravegnini G., De Leo A., Nannini M., Ferioli M., Morganti A.G., Pantaleo M.A., De Iaco P., Perrone A.M. |
| المصدر: | Cancers Cancers, Vol 13, Iss 5808, p 5808 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Leiomyosarcoma, fertility-sparing, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Assisted reproductive treatment, assisted reproductive treatments, Medicine, Stage (cooking), sarcomas, Cervix, RC254-282, Gynecology, Pregnancy, Endometrial stromal sarcoma, Hysterectomy, Uterine sarcoma, business.industry, Standard treatment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Sarcoma, medicine.disease, uterine cancers, medicine.anatomical_structure, Oncology, Gynecological cancer, gynecological cancers, Systematic Review, business |
| الوصف: | Simple Summary Uterine sarcomas can affect patients of reproductive age. In this setting, the chance of a fertility-sparing treatment would allow women to become pregnant. In the literature, only a few experiences of fertility-sparing treatment of uterine sarcomas have been reported; however, the oncological safety and reproductive outcomes remain unclear. The aim of this systematic review is to report and summarize all the published evidence about the fertility-sparing approach in these rare and heterogenous tumors, and to help physicians in making clinical decisions. Abstract Uterine sarcomas are rare cancers, sometimes diagnosed in women of childbearing age. Hysterectomy is the standard treatment in early stages. The option of lesion removal to save fertility is described in the literature, but it is still considered experimental. The objective of this systematic review is to report on the available evidence on the reproductive and oncological outcomes of fertility-sparing treatment in women with uterine sarcomas. PubMed, Scopus and Cochrane Central Register of Controlled Trials were searched between 1 January 2011 and 21 June 2021 for publications in English about women with uterine sarcoma treated with a fertility-sparing intervention. Thirty-seven studies were included for a total of 210 patients: 63 low-grade endometrial stromal sarcomas, 35 embryonal rhabdomyosarcomas of the cervix, 19 adenosarcomas, 7 leiomyosarcomas and 2 uterine tumors resembling an ovarian sex cord. Conservative treatment ensured pregnancy in 32% of cases. In terms of oncological outcomes, relapse was related to histology and the worst prognosis was reported for leiomyosarcoma, followed by low-grade endometrial stromal sarcoma, which relapsed in 71% and 54% of cases, respectively. The highest death rate was associated with leiomyosarcoma (57.1%). This study demonstrated that fertility-sparing treatments may be employed in selected cases of early stage uterine sarcoma. |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| تدمد: | 2072-6694 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d943ca523381dba677de24e28865b6e http://europepmc.org/articles/PMC8616470 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8d943ca523381dba677de24e28865b6e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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