التفاصيل البيبلوغرافية
العنوان:
Design and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators
المؤلفون:
Garrett Berlond Minne , Michel Surkyn , Harrie J.M. Gijsen , Francois Paul Bischoff , Nigel Austin , Marc Mercken , Didier Berthelot , Chiara Zavattaro , Ishtiyaque Ahmad , Gregor James Macdonald , Adriana Ingrid Velter , Michel Anna Jozef De Cleyn , Deborah Dhuyvetter , Sven Franciscus Anna Van Brandt , Serge Maria Aloysius Pieters , Yves Emiel Maria Van Roosbroeck , Swapan Kumar Samanta , Herman Borghys
المصدر:
Bioorganicmedicinal chemistry letters . 29(14)
سنة النشر:
2019
مصطلحات موضوعية:
Indole test , Indoles , Series (mathematics) , Stereochemistry , Organic Chemistry , Clinical Biochemistry , Pharmaceutical Science , Biochemistry , In vitro , chemistry.chemical_compound , Structure-Activity Relationship , medicine.anatomical_structure , chemistry , In vivo , Drug Design , Drug Discovery , medicine , Molecular Medicine , Potency , Imidazole , Humans , γ secretase , Amyloid Precursor Protein Secretases , Molecular Biology , Nucleus
الوصف:
The discovery, design and synthesis of a new series of GSMs is described. The classical imidazole heterocycle has been replaced by a cyano group attached to an indole nucleus. The exploration of this series has led to compound 26-S which combined high in vitro and in vivo potency with an acceptable drug-like profile.
تدمد:
1464-3405
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9f458af2fb6e368fbdd2185f1f9926 https://pubmed.ncbi.nlm.nih.gov/31122869
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....8d9f458af2fb6e368fbdd2185f1f9926
قاعدة البيانات:
OpenAIRE
