The analysis of factors associated with progression of isolated terminal ileal lesions
| العنوان: | The analysis of factors associated with progression of isolated terminal ileal lesions |
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| المؤلفون: | Chu Yanjun, Zhao Wugan, Zhang Fangbin, Zheng Cong, Hao Weiwei, Xu Feng |
| المصدر: | PLoS ONE, Vol 9, Iss 3, p e90797 (2014) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Abdominal pain, Colonoscopy, lcsh:Medicine, Logistic regression, Gastroenterology, Intestinal mucosa, Crohn Disease, Medicine, Prospective Studies, Young adult, Intestinal Mucosa, Prospective cohort study, lcsh:Science, Gastrointestinal agent, Multidisciplinary, medicine.diagnostic_test, Middle Aged, Treatment Outcome, Disease Progression, Regression Analysis, Small Intestine, Female, medicine.symptom, Research Article, Adult, medicine.medical_specialty, China, Clinical Research Design, Gastroenterology and Hepatology, Minimally Invasive Surgery, Autoimmune Diseases, Young Adult, Gastrointestinal Agents, Ileum, Internal medicine, Humans, business.industry, Inflammatory Bowel Disease, lcsh:R, Endoscopy, Abdominal Pain, Log-rank test, Celiac Disease, Logistic Models, Clinical Immunology, Surgery, lcsh:Q, business |
| الوصف: | Objective To assess the factors associated with the progression of isolated terminal ileal lesions (ITILs) at colonoscopy in Chinese patients. Methods Patients diagnosed with ITILs were enrolled. The ileoscopy was performed by two experienced gastroenterologists every 52 weeks. A logistic regression analysis was used to elucidate the factors associated with Crohn's disease (CD) and mucosal healing. A log rank test was used to assess the differences of the cumulative proportion of CD and mucosal healing in different groups at different times. Results (1) A total of 34 patients were included and no patient had taken nonsteroidal anti-inflammatory drug in the last 6 months; eight (23.5%) patients had a clinical diagnosis of CD, 14 (41.2%) patients achieved mucosal healing, and 12 (35.3%) patients showed no significant changes in the lesions at last follow-up. (2) The logistic regression analysis showed that only abdominal pain was a factor in the ITIL disease outcomes. (3) The cumulative proportion of CD in the abdominal pain group after 3 years was statistically higher than that in the non-abdominal pain group (42.7% vs. 6.2%, χ2 = 10.129, P = 0.001). However, the cumulative proportion of mucosal healing in the non-abdominal pain group was statistically higher than that in the abdominal pain group (73.3% vs. 5.6%, χ2 = 5.225, P = 0.022). (4) The numbers of lesions observed on the initial colonoscopy exams and the initial histologic findings were not related to the ITIL disease outcomes. Conclusions Clinical symptoms may be related to ITIL disease outcomes. Patients with abdominal pain had a high likelihood of CD, whereas those without abdominal pain had a high likelihood of mucosal healing. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da759924334af843896a2b78d3f7e8c http://europepmc.org/articles/PMC3953212?pdf=render |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8da759924334af843896a2b78d3f7e8c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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