Borrelia-induced cytokine production is mediated by spleen tyrosine kinase (Syk) but is Dectin-1 and Dectin-2 independent
| العنوان: | Borrelia-induced cytokine production is mediated by spleen tyrosine kinase (Syk) but is Dectin-1 and Dectin-2 independent |
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| المؤلفون: | Frank Koentgen, Frank L. van de Veerdonk, Shih-Chin Cheng, Mihai G. Netea, Kathrin Buffen, Leo A. B. Joosten, Ineke Verschueren, Marije Oosting |
| المصدر: | Cytokine, 76, 2, pp. 465-72 Cytokine, 76, 465-72 |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, medicine.medical_treatment, Immunology, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Syk, Inflammation, Stimulation, Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9], Biochemistry, Microbiology, Mice, Borrelia, medicine, Immunology and Allergy, Animals, Syk Kinase, Lectins, C-Type, Borrelia burgdorferi, Candida albicans, Receptor, Molecular Biology, Mice, Knockout, biology, Intracellular Signaling Peptides and Proteins, Hematology, Protein-Tyrosine Kinases, biology.organism_classification, bacterial infections and mycoses, Mice, Inbred C57BL, Cytokine, Cytokines, Female, medicine.symptom |
| الوصف: | Contains fulltext : 151986.pdf (Publisher’s version ) (Closed access) Although it is known that Borrelia species express sugar-like structures on their outer surface, not much is known about the role of these structures in immune recognition by host cells. Fungi, like Candida albicans, are mainly recognized by C-type lectin receptors, in specific Dectin-1 and Dectin-2. In this study we assessed the role of Dectin-1 and Dectin-2 in the recognition process of Borrelia spirochetes. Using specific inhibitors against these receptors on human cells did not influenced cytokine production. Individuals carrying a SNP leading to an early stop codon in the DECTIN-1 gene also did not lead to differential induction of Borrelia-dependent cytokines. After injection of live Borrelia into knee joints of Dectin-2 deficient mice a trend towards lower inflammation was observed. Inhibition of Syk in human cells resulted in lower cytokine production after Borrelia stimulation. In conclusion, Dectin-1 and Dectin-2 seem not to play a major role in Borrelia recognition or Borrelia-induced inflammation. However, Syk seems to be involved in Borrelia-induced cytokine production. |
| وصف الملف: | application/pdf |
| تدمد: | 1096-0023 1043-4666 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1167475046c2ec63e32f8e55c8fad5 https://pubmed.ncbi.nlm.nih.gov/26297607 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8e1167475046c2ec63e32f8e55c8fad5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10960023 10434666 |
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