Can Immobilized Artificial Membrane Chromatography Support the Characterization of Antimicrobial Peptide Origin Derivatives?
| العنوان: | Can Immobilized Artificial Membrane Chromatography Support the Characterization of Antimicrobial Peptide Origin Derivatives? |
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| المؤلفون: | Katarzyna E. Greber, Hanna Kapica, Monika Pastewska, Wiesław Sawicki, Wojciech Kamysz, Krzysztof Rolka, Krzesimir Ciura, Natalia Ptaszyńska, Anna Łęgowska |
| المصدر: | Antibiotics, Vol 10, Iss 1237, p 1237 (2021) Antibiotics |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Microbiology (medical), cell-penetrating peptide (CPP), antimicrobial peptide, medicine.drug_class, Antibiotics, Antimicrobial peptides, Synthetic membrane, Peptide, RM1-950, Biochemistry, Microbiology, medicine, Cationic Lipopeptides, Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics, chemistry.chemical_classification, Chromatography, biology, Chemistry, Communication, transportan 10 (TP10-NH2), Antimicrobial, biology.organism_classification, Ciprofloxacin, Infectious Diseases, short cationic lipopeptides, Therapeutics. Pharmacology, IAM-HPLC, Bacteria, medicine.drug |
| الوصف: | The emergence and spread of multiple drug-resistant bacteria strains caused the development of new antibiotics to be one of the most important challenges of medicinal chemistry. Despite many efforts, the commercial availability of peptide-based antimicrobials is still limited. The presented study aims to explain that immobilized artificial membrane chromatography can support the characterization of antimicrobial peptides. Consequently, the chromatographic experiments of three groups of related peptide substances: (i) short cationic lipopeptides, (ii) citropin analogs, and (iii) conjugates of ciprofloxacin and levofloxacin, with a cell-penetrating peptide were discussed. In light of the discussion of the mechanisms of action of these compounds, the obtained results were interpreted. |
| تدمد: | 2079-6382 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2c1ca3900f01ee711615f8a98d9ff9 https://doi.org/10.3390/antibiotics10101237 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8e2c1ca3900f01ee711615f8a98d9ff9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20796382 |
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