Diabetes-altered gene expression in rat skeletal muscle corrected by oral administration of vanadyl sulfate
| العنوان: | Diabetes-altered gene expression in rat skeletal muscle corrected by oral administration of vanadyl sulfate |
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| المؤلفون: | Lai-Har Chi, Debbie C. Crans, Zihua Hu, Yulan Liang, Gail R. Willsky, Daniel P. Gaile |
| المصدر: | Physiological Genomics. 26:192-201 |
| بيانات النشر: | American Physiological Society, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Blood Glucose, Male, medicine.medical_specialty, Vanadium Compounds, Physiology, Administration, Oral, Gene Expression, Vanadium, chemistry.chemical_element, Fatty Acids, Nonesterified, Biology, Diabetes Mellitus, Experimental, chemistry.chemical_compound, Oral administration, Diabetes mellitus, Internal medicine, Hyperlipidemia, Gene expression, Genetics, medicine, Animals, Hypoglycemic Agents, Rats, Wistar, Muscle, Skeletal, Triglycerides, Oligonucleotide Array Sequence Analysis, Analysis of Variance, Reverse Transcriptase Polymerase Chain Reaction, Vanadyl sulfate, Skeletal muscle, Lipid Metabolism, medicine.disease, Streptozotocin, Rats, Oxidative Stress, Cholesterol, medicine.anatomical_structure, Endocrinology, chemistry, Hyperglycemia, Signal Transduction, medicine.drug |
| الوصف: | Treatment with vanadium, a representative of a class of antidiabetic compounds, alleviates diabetic hyperglycemia and hyperlipidemia. Oral administration of vanadium compounds in animal models and humans does not cause clinical symptoms of hypoglycemia, a common problem for diabetic patients with insulin treatment. Gene expression, using Affymetrix arrays, was examined in muscle from streptozotocin-induced diabetic and normal rats in the presence or absence of oral vanadyl sulfate treatment. This treatment affected normal rats differently from diabetic rats, as demonstrated by two-way ANOVA of the full array data. Diabetes altered the expression of 133 genes, and the expression of 30% of these genes dysregulated in diabetes was normalized by vanadyl sulfate treatment. For those genes, the ratio of expression in normal animals to the expression in diabetic animals showed a strong negative correlation with the ratio of expression in diabetic animals to the expression in diabetic animals treated with vanadyl sulfate ( P = −0.85). The genes identified belong to six major metabolic functional groups: lipid metabolism, oxidative stress, muscle structure, protein breakdown and biosynthesis, the complement system, and signal transduction. The identification of oxidative stress genes, coupled with the known oxidative chemistry of vanadium, implicates reactive oxygen species in the action of this class of compounds. These results imply that early transition metals or compounds formed from their chemical interactions with other metabolites may act as general transcription modulators, a role not usually associated with this class of compounds. |
| تدمد: | 1531-2267 1094-8341 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4cd7a0f16c83681aa640eb5b98c5d0 https://doi.org/10.1152/physiolgenomics.00196.2005 |
| رقم الأكسشن: | edsair.doi.dedup.....8e4cd7a0f16c83681aa640eb5b98c5d0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15312267 10948341 |
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