Acquisition of aberrant DNA methylation is associated with frailty in the very old: findings from the Newcastle 85+ Study
| العنوان: | Acquisition of aberrant DNA methylation is associated with frailty in the very old: findings from the Newcastle 85+ Study |
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| المؤلفون: | van Otterdijk Sd, John C. Mathers, Hannah E. Gautrey, Gordon Strathdee, Karen Davies, Carmen Martin-Ruiz, J. Collerton, Thomas B. L. Kirkwood, Carol Jagger, von, Zglinicki, T |
| المصدر: | Biogerontology. 15:317-328 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Aged, 80 and over, Genetics, Aging, education.field_of_study, Frail Elderly, Population, Promoter, Odds ratio, Methylation, DNA Methylation, Biology, Polymerase Chain Reaction, CpG site, DNA methylation, Humans, Pyrosequencing, CpG Islands, Epigenetics, Geriatrics and Gerontology, education, Gerontology, Aged |
| الوصف: | Frailty is a major health problem in older people and, as the population ages, identification of its underlying biological mechanisms will be increasingly important. DNA methylation patterns within genomic DNA change during ageing and alterations in DNA methylation, particularly at gene promoter regions, can lead to altered gene expression. However the importance of altered DNA methylation in frailty is largely unknown. Using cross-sectional data from the Newcastle 85+ Study (all participants aged 85 years) frailty was operationalized by the Fried model. DNA methylation levels were assessed by highly quantitative pyrosequencing at the gene promoter associated CpG islands from a panel of five age-related methylation marker loci and at LINE-1 repetitive elements (as a surrogate for genome-wide methylation). While genome-wide methylation (as assessed at LINE-1 elements) showed no association with frailty status, there was a clear association between CpG island methylation and frailty. When compared to participants with CpG island methylation levels in the combined middle two (referent) quartiles, those in the lowest quartile had significantly decreased odds of frailty [odds ratio 0.47 (95 % CI 0.26-0.85); n = 321, p = 0.013]. Overall this study suggests a potential role for age-related changes in CpG island methylation in the development of frailty. |
| تدمد: | 1573-6768 1389-5729 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e54f52ca29ee9b5db8834512e3b3aa2 https://doi.org/10.1007/s10522-014-9500-9 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8e54f52ca29ee9b5db8834512e3b3aa2 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15736768 13895729 |
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