SERPINE1 associated with remodeling of the tumor microenvironment in colon cancer progression: a novel therapeutic target
| العنوان: | SERPINE1 associated with remodeling of the tumor microenvironment in colon cancer progression: a novel therapeutic target |
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| المؤلفون: | Zuolong Liu, Xiangwei Meng, Li Pang, Shaokun Wang |
| المصدر: | BMC Cancer BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021) |
| بيانات النشر: | BioMed Central, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Stromal cell, Colorectal cancer, Cell, Biology, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Immune system, Immunity, Plasminogen Activator Inhibitor 1, Genetics, medicine, Humans, Tumor-infiltrating immune cells, RC254-282, Tumor microenvironment, Research, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, biochemical phenomena, metabolism, and nutrition, medicine.disease, Prognosis, Survival Analysis, Colon cancer, Gene Expression Regulation, Neoplastic, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Colonic Neoplasms, Cancer research, Carcinogenesis, Infiltration (medical), SERPINE1 |
| الوصف: | Background The change of immune cell infiltration essentially influences the process of colorectal cancer development. The infiltration of immune cells can be regulated by a variety of genes. Thus, modeling the immune microenvironment of colorectal cancer by analyzing the genes involved can be more conducive to the in-depth understanding of carcinogenesis and the progression thereof. Methods In this study, the number of stromal and immune cells in malignant tumor tissues were first estimated by using expression data (ESTIMATE) and cell-type identification with relative subsets of known RNA transcripts (CIBERSORT) to calculate the proportion of infiltrating immune cell and stromal components of colon cancer samples from the Cancer Genome Atlas database. Then the relationship between the TMN Classification and prognosis of malignant tumors was evaluated. Results By investigating differentially expressed genes using COX regression and protein-protein interaction network (PPI), the candidate hub gene serine protease inhibitor family E member 1 (SERPINE1) was found to be associated with immune cell infiltration. Gene Set Enrichment Analysis (GSEA) further projected the potential pathways with elevated SERPINE1 expression to carcinogenesis and immunity. CIBERSORT was subsequently utilized to investigate the relationship between the expression differences of SERPINE1 and immune cell infiltration and to identify eight immune cells associated with SERPINE1 expression. Conclusion We found that SERPINE1 plays a role in the remodeling of the colon cancer microenvironment and the infiltration of immune cells. |
| اللغة: | English |
| تدمد: | 1471-2407 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6bced9707b6181de431f21aff1daf8 http://europepmc.org/articles/PMC8254339 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8e6bced9707b6181de431f21aff1daf8 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14712407 |
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