Gastrointestinal (GI)-Specific patient reported outcomes instruments differentiate between renal transplant patients with or without GI symptoms: results from a South American cohort
| العنوان: | Gastrointestinal (GI)-Specific patient reported outcomes instruments differentiate between renal transplant patients with or without GI symptoms: results from a South American cohort |
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| المؤلفون: | Ruben Schiavelli, Ana M Linchenco, Jacqueline Pefaur, A.B. Otero, Luis Gaite, Clemente Raimondi, Mary Kay Margolis, Gerardo Machnicki |
| المصدر: | Health and Quality of Life Outcomes Health and Quality of Life Outcomes, Vol 6, Iss 1, p 53 (2008) |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Psychometrics, Intraclass correlation, lcsh:Computer applications to medicine. Medical informatics, Cohort Studies, Quality of life, Rating scale, Internal medicine, Surveys and Questionnaires, Medicine, Humans, Longitudinal Studies, business.industry, Research, Public Health, Environmental and Occupational Health, Discriminant validity, Construct validity, Reproducibility of Results, General Medicine, Middle Aged, South America, Kidney Transplantation, Gastrointestinal Tract, Cross-Sectional Studies, Cohort, Physical therapy, Quality of Life, lcsh:R858-859.7, Female, business, Immunosuppressive Agents, Cohort study |
| الوصف: | Background Immunosuppressive therapies have burdensome side effects which may lead to sub-therapeutic dosing and non-compliance. Patients on different immunosuppressant regimens may feel less bothered by Gastrointestinal (GI) side effects or report better health-related quality of life (HRQL). We evaluated the reliability and validity of two GI-specific outcome instruments (Gastrointestinal Symptom Rating Scale (GSRS; higher scores = increased severity) and Gastrointestinal Quality of Life Index (GIQLI; higher scores = better GI-specific HRQL)) in renal transplant patients in South America. Methods Data from 5 South American centers participating in an international, longitudinal, observational study were analyzed. Patients were ≥ 1 month post transplant and on mycophenolate mofetil (MMF) and a calcineurin inhibitor. Patients completed the GSRS, GIQLI, and Psychological General Well-Being (PGWB; higher scores = better HRQL) Index at baseline and at 4–6 weeks. Internal consistency, test-retest reliability and construct and discriminant validity were assessed. Results Sixty-two participants were enrolled. Mean age was 42 years; mean time since transplant was 3.3 years; 57% were male; 65% received a deceased organ transplant and 68%had GI events. The GSRS and GIQLI demonstrated high internal consistency (Cronbach's alphas 0.72–0.96). Test-retest reliability was adequate (intraclass correlation coefficient > 0.6) for all GIQLI subscales and all GSRS subscales except Diarrhea and Reflux syndrome. Correlations between the GSRS and PGWB were moderate (range: -0.21 to -0.53, all p < 0.001 except 6 correlations with p < 0.05); correlations between the GIQLI and PGWB were higher (range: 0.36 to 0.71 p < 0.001), indicating good construct validity. The GSRS and GIQLI demonstrated good discriminant validity, as they clinically and statistically distinguished between patients with and without GI complaints and among patients with varying GI complication severity. Patients with GI complaints reported higher GSRS scores than patients without complaints (all p < 0.001). GIQLI scores were lower in patients with GI complaints than patients without complaints (all p < 0.001). The GSRS and GIQLI differentiated among patients with four GI severity levels (overall Kruskall-Wallis test p < 0.001, except for one scale). The GSRS and GIQLI are acceptable for use in South American renal transplant patients. These two instruments demonstrate adequate reliability and validity. Patients with GI complaints reported poor HRQL and strategies are needed to improve patients' HRQL. |
| تدمد: | 1477-7525 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8b15990f6b9a4d722005105293f0b6 https://pubmed.ncbi.nlm.nih.gov/18644133 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8f8b15990f6b9a4d722005105293f0b6 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14777525 |
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