The emerging role of miR-10 family in gastric cancer
| العنوان: | The emerging role of miR-10 family in gastric cancer |
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| المؤلفون: | Yanfen Shi, Ziyi Li, Fang Liu, Wei Xu, Zuolong Liu |
| المصدر: | Cell Cycle |
| بيانات النشر: | Informa UK Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Antineoplastic Agents, Apoptosis, Review, Biology, medicine.disease_cause, Metastasis, Cell Movement, Stomach Neoplasms, Cancer stem cell, microRNA, medicine, Animals, Humans, Neoplasm Invasiveness, Receptors, Immunologic, Molecular Biology, Cell Proliferation, Membrane Glycoproteins, Cell growth, Cell Cycle, Cancer, Cell Biology, Cell cycle, medicine.disease, Gene Expression Regulation, Neoplastic, Drug Resistance, Neoplasm, Cancer cell, Neoplastic Stem Cells, Cancer research, Carcinogenesis, Signal Transduction, Developmental Biology |
| الوصف: | Evidence has demonstrated that miRNAs play an irreplaceable role in tumorigenesis and progression of a broad range of cancers, including gastric cancer. Among these miRNAs, miR-10a and miR-10b have been identified to critically participate in gastric carcinogenesis and malignant progression. In this review, we briefly describe the role of miR-10a and miR-10b in gastric cancer, especially in the regulation of cell proliferation, apoptosis, cell cycle, migration, invasion and metastasis, drug resistance, and cancer stem cells. Furthermore, we highlight several compounds that target the miR-10 family and exhibit antitumor activity in cancer cells. Moreover, we conclude that targeting the miR-10 family might be a promising approach for the treatment of gastric cancer. |
| تدمد: | 1551-4005 1538-4101 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fca4d076d2a3737fa3948985cd88224 https://doi.org/10.1080/15384101.2021.1949840 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8fca4d076d2a3737fa3948985cd88224 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15514005 15384101 |
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