Suitability of Placental Blood Samples of Newborns for Pre-Transfusion Testing
| العنوان: | Suitability of Placental Blood Samples of Newborns for Pre-Transfusion Testing |
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| المؤلفون: | Erika L. Baker, Jinous Saremian, Rana Alissa, Patty D. Williams, Jennifer A. Hipp, Agnes Aysola |
| المصدر: | Frontiers in Pediatrics Frontiers in Pediatrics, Vol 9 (2021) |
| بيانات النشر: | Frontiers Media SA, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Heel, Concordance, less invasive, Pediatrics, RJ1-570, 03 medical and health sciences, Heel stick, 0302 clinical medicine, McNemar's test, 030225 pediatrics, ABO blood group system, medicine, 030212 general & internal medicine, Original Research, natural, placental blood, Pre transfusion, Obstetrics, business.industry, pre-transfusion testing, Gestational age, medicine.anatomical_structure, heel stick, Pediatrics, Perinatology and Child Health, business, Placental blood |
| الوصف: | Objective: To show concordance between heel stick and placental blood sample pairs for newborns' pre-transfusion testing and to validate placental blood's tube and gel methodology.Methods: Placental samples were collected for pre-transfusion testing at birth from 78 singleton and twin newborns admitted to our Mother–Baby Unit to compare with the results of heel stick samples taken from same newborns. Gestational age ≥35 weeks, weight ≥2,000 g. The study was approved by the Institutional Review Board (IRB). Informed consent was obtained from newborn parents. ABO blood group, Rhesus factor (Rh), direct antiglobulin test (DAT), and antibody screen were performed. Ortho ProVue Analyzer was used for tube and gel methods. McNemar's test for paired categorical data was performed.Results: One hundred percent concordance in 78 pairs for ABO and Rh. Seventy-four pairs were tested for antibodies, 72 were both negative, 1 was both positive, and 1 gave discordant result. Ninety-nine percent concordance, p = 0.999. Sixty-five pairs were both DAT negative, seven were both DAT positive, and six gave discordant results. Ninety-two percent concordance, p = 0.68. Placental blood gave identical results comparing tube with gel methods.Conclusions: Placental blood is suitable for pre-transfusion testing and can replace heel sticks. Placental blood tube and gel methods are validated. |
| تدمد: | 2296-2360 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd4915e0529a50174789995877ecae6 https://doi.org/10.3389/fped.2021.661321 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....8fd4915e0529a50174789995877ecae6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22962360 |
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