Effects of polymer-based, silver nanoparticle-coated silicone splints on the nasal mucosa of rats
| العنوان: | Effects of polymer-based, silver nanoparticle-coated silicone splints on the nasal mucosa of rats |
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| المؤلفون: | Gamze Yurdakan, Baki Hazer, Duygu Erdem, Canan Külah, Aykut Erdem Dinç, Sultan Şevik Eliçora, Özlem A. Kalaycı |
| المساهمون: | Zonguldak Bülent Ecevit Üniversitesi |
| المصدر: | European Archives of Oto-Rhino-Laryngology. 274:1535-1541 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Silver, Polyethylene glycol, Nasal tampon, Secondary infection, Nasal Surgical Procedures, Silicones, Metal Nanoparticles, Mucous membrane of nose, 02 engineering and technology, medicine.disease_cause, Gastroenterology, Silver nanoparticle, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Silicone, Internal medicine, medicine, Animals, Surgical Wound Infection, Tampons, Surgical, Nasal splint, 030223 otorhinolaryngology, Nasal Septum, business.industry, General Medicine, 021001 nanoscience & nanotechnology, Antimicrobial, Anti-Bacterial Agents, Rats, Surgery, Disease Models, Animal, Nasal Mucosa, Splints, Treatment Outcome, Otorhinolaryngology, chemistry, Ag nanoparticle, 0210 nano-technology, Complication, business, Staphylococcus |
| الوصف: | Infection is a serious complication after nasal packing that otolaryngologists seek to avoid. The aim of this study is to investigate the use of silver (Ag) nanoparticle, which serves as antimicrobial agents, with nasal tampons. The study design is an experimental animal model and the setting is tertiary referral center. Twenty-four rats were randomized into the following four groups: (1) control group (n = 6); (2) silicone nasal splint (SNS) group (n = 6); (3) polypropylene-grafted polyethylene glycol (PP-g-PEG) amphiphilic graft copolymer-coated SNS group (n = 6); and (4) Ag nanoparticle-embedded PP-g-PEG (Ag-PP-g-PEG) amphiphilic graft copolymer-coated SNS group (n = 6). These tampons were applied to rats for 48 h, after which they were removed in a sterile manner, and the rats were sacrificed. The nasal septa of the rats were excised, and assessments of tissue changes in the nasal mucosa were compared among the groups. The removed tampons were microbiologically examined, and quantitative analyses were made. When the groups were compared microbiologically, there were no significant differences in bacterial colonization rates of coagulase-negative Staphylococcus spp. among the three groups (p = 0.519), but there was a statistically significant difference among bacterial colonization rates of Heamophilus parainfluenzae and Corynebacterium spp. (p = 0.018, p = 0.004). We found that H. parainfluenzae grew less robustly in the Ag-PP-g-PEG than the PP-g-PEG group (p = 0.017). However, we found no significant difference between the Ag-PP-g-PEG and SNS groups, or between the SNS and PP-g-PEG groups. The growth of Corynebacterium spp. did not differ significantly between the Ag-PP-g-PEG and SNS groups (p = 1.000). When Group 4 was compared with Group 2, the former showed less inflammation. Compared with other tampons, Ag-PP-g-PEG amphiphilic graft copolymer-coated silicone nasal tampons caused less microbiological colonization and inflammation. Therefore, the use of these tampons may prevent secondary infections and reduce the risk of developing complications by minimizing tissue damage. © 2016, Springer-Verlag Berlin Heidelberg. |
| وصف الملف: | application/pdf |
| تدمد: | 1434-4726 0937-4477 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd6d34eae70576b5c85f9767f74363b https://doi.org/10.1007/s00405-016-4394-6 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....8fd6d34eae70576b5c85f9767f74363b |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14344726 09374477 |
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