Gender-Based Violence, Physiological Stress, and Inflammation: A Cross-Sectional Study
| العنوان: | Gender-Based Violence, Physiological Stress, and Inflammation: A Cross-Sectional Study |
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| المؤلفون: | Susan M. Graham, Eleanor Brindle, Madeleine Heller, Neha Chohan, Sarah T. Roberts, Jacquiline Ngina, Juma Shafi, Linnet Masese, Vrasha Chohan, R. Scott McClelland |
| المصدر: | Journal of Women's Health. 27:1152-1161 |
| بيانات النشر: | Mary Ann Liebert Inc, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Hydrocortisone, Cross-sectional study, Human immunodeficiency virus (HIV), Physiology, Enzyme-Linked Immunosorbent Assay, Inflammation, Gender-Based Violence, Hiv risk, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Stress, Physiological, medicine, Humans, 030212 general & internal medicine, Physiological stress, Sex Workers, Multivariable linear regression, Interleukin-6, business.industry, Female sex, Original Articles, General Medicine, Kenya, C-Reactive Protein, Cross-Sectional Studies, Biomarker (medicine), Female, medicine.symptom, business, Biomarkers, 030217 neurology & neurosurgery, Hair |
| الوصف: | Background: Female sex workers (FSWs) are at high risk for gender-based violence (GBV) and HIV infection. This study aimed to identify associations between GBV exposure in the past 12 months and biomarkers of physiologic stress and inflammation that may play a role in increased HIV risk among Kenyan FSWs. Materials and Methods: Participating women responded to a detailed questionnaire on GBV and mental health. Plasma was collected for assessment of systemic C-reactive protein (CRP) and interleukin-6 (IL-6) levels. Hair proximal to the scalp was collected to measure cortisol concentration. CRP and IL-6 were measured by enzyme-linked immunosorbent assay, and hair cortisol concentration was determined by enzyme immunoassay. Log-transformed biomarker values were compared across GBV exposure categories using Kruskal–Wallis or Wilcoxon rank sum tests. Multivariable linear regression was used to explore associations between recent GBV and hair cortisol concentration. Results: Two hundred eighty-three women enrolled, of whom 112 (39.6%) reported physical, sexual, or emotional violence in the past 12 months, 134 (47.3%) reported more remote exposure, and 37 (13.1%) reported no exposure. CRP and IL-6 levels did not differ across groups (p = 0.57 and p = 0.62, respectively). Among 141 women who provided hair, cortisol concentrations were higher among recently exposed women compared to the other two groups combined (p = 0.02). In multivariable regression, recently exposed women had higher hair cortisol levels than remotely exposed or unexposed women (adjusted beta = 0.52, 95% confidence interval 0.02–1.02, p = 0.04). Conclusions: While CRP and IL-6 levels did not differ by GBV category, recent GBV was associated with increased hair cortisol concentration. GBV-related increases in cortisol could affect health outcomes and merit study in relation to HIV acquisition risk. |
| تدمد: | 1931-843X 1540-9996 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90962ae0f2ee24c6c46a015304508b3f https://doi.org/10.1089/jwh.2017.6743 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....90962ae0f2ee24c6c46a015304508b3f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1931843X 15409996 |
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