Safety and Immunogenicity of Early Measles Vaccination in Children Born to HIV-Infected Mothers in the United States: Results of Pediatric AIDS Clinical Trials Group (PACTG) Protocol 225
| العنوان: | Safety and Immunogenicity of Early Measles Vaccination in Children Born to HIV-Infected Mothers in the United States: Results of Pediatric AIDS Clinical Trials Group (PACTG) Protocol 225 |
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| المؤلفون: | Sulachni, Chandwani, Judy, Beeler, Hong, Li, Susette, Audet, Betsy, Smith, John, Moye, David, Nalin, Keith, Krasinski, Thomas, Nevin |
| المصدر: | The Journal of Infectious Diseases. 204:S179-S189 |
| بيانات النشر: | Oxford University Press (OUP), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, Pediatrics, medicine.medical_specialty, Pediatric AIDS, Measles-Mumps-Rubella Vaccine, Measles Vaccine, HIV Infections, Antibodies, Viral, Vaccines, Attenuated, Rubella, Measles, Viral Matrix Proteins, Pregnancy, medicine, Humans, Immunology and Allergy, Immunization Schedule, Reactogenicity, business.industry, Antibody titer, Measles Vaccine Safety and Effectiveness, medicine.disease, Antibodies, Neutralizing, Infectious Disease Transmission, Vertical, United States, CD4 Lymphocyte Count, Vaccination, Infectious Diseases, Child, Preschool, Immunology, Female, Measles vaccine, business |
| الوصف: | Background. PACTG (Pediatric AIDS Clinical Trials Group) 225, a multicenter, randomized, open-label trial in the United States evaluated reactogenicity and immunogenicity of 2 vaccination regimens: monovalent measles vaccine (Attenuvax) at 6 months of age and measles, mumps, and rubella, live attenuated (MMRII) vaccine at 12 months of age (2D), or only MMRII at 12 months of age (1D) in human immunodeficiency virus–infected (HIV-infected) (POS) and uninfected (NEG) children in the pre–highly active antiretroviral therapy (pre-HAART) period. Methods. Plaque-reduction neutralization (PRN) of measles-neutralizing antibody titers were evaluated at study weeks 0, 6, 26, 32, 52, and 130 (∼3 years of age). Results. The 110 subjects included: 65 2DNEG; 30 1DNEG; 7 2DPOS and 8 1DPOS. Vaccinations (n = 175) were associated with no adverse experiences >Grade 2 except for Grade 3 fever (n = 2, 1 1DPOS and 1 1DNEG). Six weeks after Attenuvax, all 2DPOS subjects (7/7) seroresponded (PRN titers ≥120 mIU/mL) with median titers significantly exceeding 2DNEG titers (2115 vs 628 mIU/mL, respectively; P = .023). At ∼3 years of age, 67% 1DPOS (4/6) and 83% 2DPOS (4/5) subjects maintained titers ≥120 mIU/mL. Prevaccination titers ≥25 mIU/mL among 2DNEG subjects correlated inversely with the likelihood of achieving titers ≥120 mIU/mL (56% vs 90%; P = .004). Conclusions. Among HIV-infected children pre-HAART, Attenuvax at 6 months was well tolerated and immunogenic. These data support the current World Health Organization (WHO) recommendation to administer a first dose of measles vaccine at 6 months of age to HIV-infected children. |
| تدمد: | 1537-6613 0022-1899 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a6f8f9c64ed8ea066af51455d8a18b https://doi.org/10.1093/infdis/jir089 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....90a6f8f9c64ed8ea066af51455d8a18b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376613 00221899 |
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