Cancer cells grown in 3D under fluid flow exhibit an aggressive phenotype and reduced responsiveness to the anti-cancer treatment doxorubicin
| العنوان: | Cancer cells grown in 3D under fluid flow exhibit an aggressive phenotype and reduced responsiveness to the anti-cancer treatment doxorubicin |
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| المؤلفون: | Marilena Loizidou, Tayebeh Azimi, Miriam Dwek |
| المصدر: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) |
| بيانات النشر: | Nature Publishing Group UK, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Cancer microenvironment, Biomaterials - proteins, Cell Survival, Receptor, ErbB-2, Cell Culture Techniques, lcsh:Medicine, Vimentin, Antineoplastic Agents, Triple Negative Breast Neoplasms, Models, Biological, Article, Breast cancer, Cell Line, Tumor, medicine, Matrix Metalloproteinase 14, Tumor Microenvironment, Humans, Doxorubicin, Viability assay, lcsh:Science, skin and connective tissue diseases, Cancer models, Cell Proliferation, Multidisciplinary, biology, business.industry, Mesenchymal stem cell, lcsh:R, Cancer, medicine.disease, Cadherins, Experimental models of disease, Gene Expression Regulation, Neoplastic, Ki-67 Antigen, Phenotype, SKBR3, Drug Resistance, Neoplasm, Cancer cell, biology.protein, Cancer research, lcsh:Q, Female, Snail Family Transcription Factors, business, medicine.drug |
| الوصف: | 3D laboratory models of cancer are designed to recapitulate the biochemical and biophysical characteristics of the tumour microenvironment and aim to enable studies of cancer, and new therapeutic modalities, in a physiologically-relevant manner. We have developed an in vitro 3D model comprising a central high-density mass of breast cancer cells surrounded by collagen type-1 and we incorporated fluid flow and pressure. We noted significant changes in cancer cell behaviour using this system. MDA-MB231 and SKBR3 breast cancer cells grown in 3D downregulated the proliferative marker Ki67 (P |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b8293bfb1c716b34312b5b2bb9fd53 http://europepmc.org/articles/PMC7374750 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....90b8293bfb1c716b34312b5b2bb9fd53 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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