Anti-viral potential of garlic (Allium sativum) and it's organosulfur compounds: A systematic update of pre-clinical and clinical data
| العنوان: | Anti-viral potential of garlic (Allium sativum) and it's organosulfur compounds: A systematic update of pre-clinical and clinical data |
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| المؤلفون: | Jamil A. Shilpi, Dipto Kumer Sarker, Satyajit D. Sarker, Razina Rouf, Evelin Tiralongo, Lutfun Nahar, Eunus S. Ali, Muhammad Torequl Islam, Shaikh Jamal Uddin |
| المصدر: | Trends in Food Science & Technology |
| بيانات النشر: | Elsevier Ltd., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, MAPK/ERK pathway, MARS-CoV, Middle East respiratory syndrome coronavirus, VV, Vaccinia virus, NA, Not available, AGE, Aged garlic extract, IAV-H1N1, IBV Influenza A virus-H1N1, Hp, Haptoglobin, Pharmacology, AdV-41, Adenovirus-41, HPV, Influenza B virus Human papillomavirus, IEG1, Immediate-early gene 1, 0302 clinical medicine, IEGs, Immediate-early genes, NK, Natural killer, OSCs, Organosulfur compounds, MAPK, Mitogen activated protein kinase, Medicine, CoV, Coronavirus, DDB, Dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethylene dioxybiphenyl-2,2′-dicarboxylate, ECHO11, Echovirus-11, SAMC, S-allyl-mercaptocysteine, HCMV, Human cytomegalovirus, HRV-2, Human rhinovirus type 2, AdV-3, Adenovirus-3, Kinase, RMCW, Recalcitrant multiple common warts, ERK, Extracellular-signal-regulated kinase, food and beverages, MDCK cells, Madin-darby canine kidney cells, SI, Selectivity index, LGE, Lipid garlic extract, SAMG, S-allyl-mercapto-glutathione, SWV, Spotted wilt virus, SAC, Serum antioxidant concentration, 030220 oncology & carcinogenesis, GRAS, Generally regarded as safe, Signal transduction, RCTs, Randomized clinical trials, Allium sativum, HSV-1, Herpes simplex virus-1, Biotechnology, HIV-1, Human immunodeficiency virus-1, PGE, Powdered garlic extract, Immunomodulatory, PRV, Porcine Rotavirus, Article, ARVI, Acute respiratory viral infection, SARS-CoV, Severe acute respiratory syndrome coronavirus, CPE, Cytopathic effect, DADS, Diallyl disulfide, 03 medical and health sciences, Immune system, ECM, Extracellular matrix, Functional food, Viral entry, PVY, Potato Virus Y, HAV, Hepatitis A virus, AIV-H9N2, Avian influenza virus-H9N2, GLRaV‐2, Grapevine leafroll‐associated virus 2, Pandemic, GO, Garlic oil, business.industry, DAS, Diallyl sulfide, MeV, Measles virus, RV-SA-11, Rotavirus SA-11, ALT, Alanine aminotransferase, HSV-2, Herpes simplex virus-2, PRRSV, Porcine reproductive and respiratory syndrome virus, GE, Garlic extract, Reverse transcriptase, PIV- 3, Parainfluenza virus-3, FDA, Food and drug administration, 030104 developmental biology, NDV, Newcastle disease virus, VSV, Vesicular stomatitis virus, CBV-3, Coxsackie B −3, DATS, Diallyl trisulfide, business, Food Science, Organosulfur compounds, SRGE, Sustained release garlic extract |
| الوصف: | Background Garlic (Allium sativum L.) is a common herb consumed worldwide as functional food and traditional remedy for the prevention of infectious diseases since ancient time. Garlic and its active organosulfur compounds (OSCs) have been reported to alleviate a number of viral infections in pre-clinical and clinical investigations. However, so far no systematic review on its anti-viral effects and the underlying molecular mechanisms exists. Scope and approach The aim of this review is to systematically summarize pre-clinical and clinical investigations on antiviral effects of garlic and its OSCs as well as to further analyse recent findings on the mechanisms that underpin these antiviral actions. PubMed, Cochrane library, Google Scholar and Science Direct databases were searched and articles up to June 2020 were included in this review. Key findings and conclusions Pre-clinical data demonstrated that garlic and its OSCs have potential antiviral activity against different human, animal and plant pathogenic viruses through blocking viral entry into host cells, inhibiting viral RNA polymerase, reverse transcriptase, DNA synthesis and immediate-early gene 1(IEG1) transcription, as well as through downregulating the extracellular-signal-regulated kinase (ERK)/mitogen activated protein kinase (MAPK) signaling pathway. The alleviation of viral infection was also shown to link with immunomodulatory effects of garlic and its OSCs. Clinical studies further demonstrated a prophylactic effect of garlic in the prevention of widespread viral infections in humans through enhancing the immune response. This review highlights that garlic possesses significant antiviral activity and can be used prophylactically in the prevention of viral infections. Highlights • Garlic have anti-viral and immune boosting properties. • Dietary intake of garlic and garlic products is suggested as a source of anti-viral agents that can prevent viral infections as a prophylactic intervention. • The organosulfur constituents of garlic contribute in prevention of viral infections. |
| اللغة: | English |
| تدمد: | 1879-3053 0924-2244 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90ce7b3943b32796f9feea02ac8147c0 http://europepmc.org/articles/PMC7434784 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....90ce7b3943b32796f9feea02ac8147c0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18793053 09242244 |
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